Blood advances · 2020
Clonal hematopoiesis in angioimmunoblastic T-cell lymphoma with divergent evolution to myeloid neoplasms.
СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
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Lewis Natasha E, Petrova-Drus Kseniya, Huet Sarah, Epstein-Peterson Zachary D, Gao Qi, Sigler Allison E, Baik Jeeyeon, Ozkaya Neval, Moskowitz Alison J, Kumar Anita, Horwitz Steven M, Zhang Yanming, Arcila Maria E, Levine Ross L, Roshal Mikhail, Dogan Ahmet, Xiao Wenbin
Аннотация
TET2 and DNMT3A mutations are frequently identified in T-cell lymphomas of T follicular helper cell origin (TCL-TFH), clonal hematopoiesis (CH), and myeloid neoplasms (MNs). The relationships among these 3 entities, however, are not well understood. We performed comprehensive genomic studies on paired bone marrow and tissue samples as well as on flow cytometry-sorted bone marrow and peripheral blood subpopulations from a cohort of 22 patients with TCL-TFH to identify shared CH-type mutations in various hematopoietic cell compartments. Identical mutations were detected in the neoplastic T-cell and myeloid compartments of 15 out of 22 patients (68%), including TET2 (14/15) and DNMT3A (10/15). Four patients developed MNs, all of which shared CH-type mutations with their TCL-TFH; additional unique genetic alterations were also detected in each patient's TCL-TFH and MN. These data demonstrate that CH is prevalent in patients with TCL-TFH and that divergent evolution of a CH clone may give rise to both TCL-TFH and MNs.