International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2026
Elenagen, a p62/SQSTM1-encoding plasmid, improves overall survival in patients with platinum-resistant ovarian cancer: a phase II trial.
СтатьяКлиническое исследование II фазыМногоцентровое исследованиеРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Krasny Sergei, Baranau Yauheni, Bakin Evgeny, Polyakov Sergey, Streltsova Olga, Zharkova Ekaterina, Filimonava Aliona, Levin Gabriel, Gabai Vladimir, Shneider Alexander
Аннотация
OBJECTIVE: Platinum-resistant ovarian cancer remains a major therapeutic challenge, with limited benefit from currently available cytotoxic agents. Elenagen is a newly developed plasmid DNA-based anti-cancer agent that encodes p62/SQSTM1 protein, a multi-functional adapter protein involved in selective autophagy, signal transduction, and modulation of the inflammatory response. We previously reported the progression-free survival outcomes of patients with platinum-resistant ovarian cancer treated with Elenagen. We report the overall survival results from a phase II randomized controlled trial comparing Elenagen plus gemcitabine with gemcitabine alone.
METHODS: This open-label, prospective, randomized, 2-center study enrolled women with platinum-resistant ovarian cancer. Patients were randomly assigned (1:1) to receive gemcitabine monotherapy (1000 mg/m2 on days 1 and 8 every 21 days) or gemcitabine plus Elenagen (2.5 mg intra-muscularly weekly). The primary end point was overall survival; secondary end points included safety, post-progression outcomes, and time-dependent analyses of Elenagen exposure. Survival was analyzed using Kaplan-Meier and Cox proportional hazards models.
RESULTS: Thirty patients (15 per arm) were evaluable for overall survival. Baseline demographic and clinical characteristics were balanced between groups. Among patients with elevated CA-125 levels (> 35 U/mL), median overall survival was 13 months (95% confidence interval [CI] 10 to 27) in the gemcitabine arm and 25 months (95% CI 17 to not reached) in the Elenagen plus gemcitabine arm (log-rank p = .031). Treatment with Elenagen was associated with a 59% reduction in the risk of death (hazard ratio 0.41, 95% CI 0.18 to 0.94, p = .036). Time-dependent and landmark analyses demonstrated a positive association between longer Elenagen exposure and improved survival (p < .001). No additional safety signals were observed compared with gemcitabine alone. Post-progression survival and subsequent therapy patterns were comparable between arms.
CONCLUSIONS: The addition of Elenagen to gemcitabine prolonged overall survival in patients with platinum-resistant ovarian cancer without increasing toxicity.
TRIAL REGISTRATION: NCT05979298, 2023-08-07.
METHODS: This open-label, prospective, randomized, 2-center study enrolled women with platinum-resistant ovarian cancer. Patients were randomly assigned (1:1) to receive gemcitabine monotherapy (1000 mg/m2 on days 1 and 8 every 21 days) or gemcitabine plus Elenagen (2.5 mg intra-muscularly weekly). The primary end point was overall survival; secondary end points included safety, post-progression outcomes, and time-dependent analyses of Elenagen exposure. Survival was analyzed using Kaplan-Meier and Cox proportional hazards models.
RESULTS: Thirty patients (15 per arm) were evaluable for overall survival. Baseline demographic and clinical characteristics were balanced between groups. Among patients with elevated CA-125 levels (> 35 U/mL), median overall survival was 13 months (95% confidence interval [CI] 10 to 27) in the gemcitabine arm and 25 months (95% CI 17 to not reached) in the Elenagen plus gemcitabine arm (log-rank p = .031). Treatment with Elenagen was associated with a 59% reduction in the risk of death (hazard ratio 0.41, 95% CI 0.18 to 0.94, p = .036). Time-dependent and landmark analyses demonstrated a positive association between longer Elenagen exposure and improved survival (p < .001). No additional safety signals were observed compared with gemcitabine alone. Post-progression survival and subsequent therapy patterns were comparable between arms.
CONCLUSIONS: The addition of Elenagen to gemcitabine prolonged overall survival in patients with platinum-resistant ovarian cancer without increasing toxicity.
TRIAL REGISTRATION: NCT05979298, 2023-08-07.