Pericardial Calcification Following Acute Myopericarditis After Initial CHOP Treatment for Mantle Cell Lymphoma: A Case Report.

A 56-year-old woman with B-cell lymphoma underwent chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP). Within 30 hours, the patient developed acute cardiotoxicity, characterized by elevated cardiac enzymes and ST-segment and T-wave (ST-T) changes on electrocardiogram (ECG), despite normal echocardiographic findings. Both ST elevations and enzyme levels spontaneously improved the following day. One week later, computed tomography (CT) revealed a newly developed high-density area on the pericardium, suggestive of early calcific deposition, which was confirmed to have progressed on follow-up imaging. While anthracycline-related cardiovascular toxicities are well documented, this case demonstrates a rare and rapid evolution from acute myopericarditis to early pericardial calcification following initial CHOP therapy. This rare presentation of early-onset cardiotoxicity in a patient with B-cell lymphoma is discussed with reference to the existing literature.