Frontiers in neuroscience · 2026
Transcriptional signatures of the cortical morphometric similarity network gradient in left temporal lobe epilepsy with different seizure symptoms.
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Lin Kanlin, Zeng Taipeng, Zhang Pan, Li Hui, Yang Pengfan, Huang Zhifeng, Chen Nuozhen, Wang Xiaoyang, Fu Liyuan, Xu Shangwen
Аннотация
BACKGROUND: Temporal lobe epilepsy (TLE) manifests with diverse seizure symptoms, including focal to bilateral tonic-clonic seizures (FBTCS), linked to widespread brain network disruptions. The role of cortical morphometric similarity (MS) network gradients and their relationship with gene expression in TLE remains unclear.
METHODS: We studied MS network gradient abnormalities through group comparisons among 87 left TLE patients (48 FBTCS-, 39 FBTCS+) and 63 healthy controls (HC). In addition, partial least squares (PLS) regression analysis was performed to investigate the association between gradient changes and whole-brain gene expression in left FBTCS+ TLE patients.
RESULTS: FBTCS+ patients showed significant reductions in the principal MS network gradient within default mode network (DMN) regions compared to healthy controls, while FBTCS- patients exhibited no such abnormalities. Gradient alterations in FBTCS+ were linked to whole-brain expression of genes involved in neurobiological pathways, cell types, and cortical layers.
CONCLUSION: FBTCS+ TLE is associated with distinct MS network gradient alterations, which may reflect underlying molecular mechanisms contributing to structural changes linked to severe seizure symptoms.
METHODS: We studied MS network gradient abnormalities through group comparisons among 87 left TLE patients (48 FBTCS-, 39 FBTCS+) and 63 healthy controls (HC). In addition, partial least squares (PLS) regression analysis was performed to investigate the association between gradient changes and whole-brain gene expression in left FBTCS+ TLE patients.
RESULTS: FBTCS+ patients showed significant reductions in the principal MS network gradient within default mode network (DMN) regions compared to healthy controls, while FBTCS- patients exhibited no such abnormalities. Gradient alterations in FBTCS+ were linked to whole-brain expression of genes involved in neurobiological pathways, cell types, and cortical layers.
CONCLUSION: FBTCS+ TLE is associated with distinct MS network gradient alterations, which may reflect underlying molecular mechanisms contributing to structural changes linked to severe seizure symptoms.