Frontiers in human neuroscience · 2026
Association of neurite orientation dispersion and density imaging with cognitive impairment in nasopharyngeal carcinoma patients with radiation-induced temporal lobe injury.
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Zeng Weike, Wen Qin, Su Yun, Peng Qingxia, Yan Zhuoheng, Chen Xinyin, Yan Xu, Qin Haodong, Li Jianing, Mao Jiaji
Аннотация
BACKGROUND: To evaluate whether neurite orientation dispersion and density imaging (NODDI) can reflect cognitive impairment (CI) in nasopharyngeal carcinoma (NPC) patients with late-delayed radiation-induced temporal lobe injury (RTLI).
METHODS: In this prospective study, 90 NPC patients with RTLI underwent structural MRI, conventional diffusion-weighted imaging, and NODDI. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA; score < 26 indicated CI). NODDI-derived parameters-intra-neurite volume fraction (ICVF), isotropic volume fraction (ISOVF), and orientation dispersion index (ODI)-and apparent diffusion coefficient (ADC) were compared between patients with and without CI. Diagnostic performance and correlations with MoCA scores were analyzed.
RESULTS: Among 90 patients, 66 had CI. CI patients exhibited significantly lower ICVF and ODI (p < 0.001, p = 0.047, respectively), while ISOVF and ADC did not differ (p > 0.05). ICVF demonstrated superior discriminative performance (AUC = 0.869) versus ODI (AUC = 0.638). Correlation analyses demonstrated a strong positive association between ICVF and the MoCA scores (ρ = 0.781, p < 0.001), a weak negative correlation for ISOVF (ρ = -0.310, p = 0.003) and ADC (ρ = -0.215, p = 0.041), and no significant correlations for ODI.
CONCLUSION: NODDI-derived ICVF is associated with CI and correlates with MoCA scores in NPC patients with RTLI.
METHODS: In this prospective study, 90 NPC patients with RTLI underwent structural MRI, conventional diffusion-weighted imaging, and NODDI. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA; score < 26 indicated CI). NODDI-derived parameters-intra-neurite volume fraction (ICVF), isotropic volume fraction (ISOVF), and orientation dispersion index (ODI)-and apparent diffusion coefficient (ADC) were compared between patients with and without CI. Diagnostic performance and correlations with MoCA scores were analyzed.
RESULTS: Among 90 patients, 66 had CI. CI patients exhibited significantly lower ICVF and ODI (p < 0.001, p = 0.047, respectively), while ISOVF and ADC did not differ (p > 0.05). ICVF demonstrated superior discriminative performance (AUC = 0.869) versus ODI (AUC = 0.638). Correlation analyses demonstrated a strong positive association between ICVF and the MoCA scores (ρ = 0.781, p < 0.001), a weak negative correlation for ISOVF (ρ = -0.310, p = 0.003) and ADC (ρ = -0.215, p = 0.041), and no significant correlations for ODI.
CONCLUSION: NODDI-derived ICVF is associated with CI and correlates with MoCA scores in NPC patients with RTLI.