Interaction Between Age and Tumor Stage in Survival Outcomes of Patients With Mantle Cell Lymphoma.
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Bangolo Ayrton, Amoozgar Behzad, Nagesh Vignesh K, McGrath Kyra, Mallipeddi Swapnika, Cash Samantha, Sandilya Ankit, Banu Rakshanda, Martine Frantz R, Gill Sarvarinder, Zhang Lili, Naeem Shafia, Mallampalli Pujita, Ram Arun, Papantoniou Dessislava, Nareeba Shallot, Baek Kwangha, Sharma Urveesh, Mondal Gopal, Bano Kausar, Gad Mary, Rokade Priya R, Kharat Monica M, Dodhia Aditya, Goud Snehal, Gavva Sahiti, Aduna Eyasu G, Siddiqui Zaed S, Palvia Aadi R, Singh Arjuninder, Nayak Akaash, Jakkula Krishna P, Jethi Achint, Thota Neeharika, Weissman Simcha
Аннотация
METHODS: Using SEER database data, this retrospective cohort study analyzes demographic and clinical variables like age, gender, stage, treatment, and marital status. Mortality risks were assessed using Cox proportional hazard regression models to identify predictors of overall mortality (OM) and cancer-specific mortality (CSM), emphasizing age-tumor stage interactions.
RESULTS: Multivariate Cox regression identified age and advanced Ann Arbor stage (II, III, and IV) as critical predictors of increased OM and MCL-specific mortality. Patients aged 80+ had the highest mortality risks (OM HR = 3.93, 95 % CI 1.33-11.64; CSM HR = 4.02, 95 % CI 1.36-11.88). Marital status was significant, with widowed individuals experiencing elevated mortality (OM HR = 1.85, 95 % CI 1.28-2.68; CSM HR = 1.81, 95 % CI 1.26-2.61). Advanced staging combined with older age showed significant risk interactions, except for Stage III, which lacked age-related significance.
CONCLUSION: Age, tumor stage, and marital status strongly influence MCL outcomes, highlighting the need for personalized management strategies. Widowed status underscores the role of social support in survival. Tailored interventions, accounting for these factors, can improve patient outcomes. Further research is essential to clarify age-stage interactions and refine therapeutic approaches.