MedElevator Войти в исследования
← Поиск публикаций

DOI 10.21203/rs.3.rs-7077810/v1

Медицинская библиотека · Research square · 2026

The Oncology Research Information Exchange Network (ORIEN) - Building a Real-World Collaborative, Patient-driven Infrastructure for Discovery Research and Precision Oncology.

Churchman Michelle L, Lu Xin, McKean David M, Radmacher Michael D, Zhang Qi, Rounbehler Robert J, Tan Aik Choon, Shaw Timothy I, Obermayer Alyssa, Grass G Daniel, Spakowicz Daniel, Tarhini Ahmad A, Shain Kenneth H, Canevarolo Rafael Renatino, Meads Mark B, Silva Ariosto S, Sudalagunta Praneeth Reddy, Manley Brandon J, Huntsman Shane, Collyar Deborah, Kolesar Jill M, Evers B Mark, Single Nancy, Edge Stephen B, Johnson Candace S, Weiner George J, McCarter Martin D, Borges Virginia F, Horne Latrisha, Lillard James W, Mudaranthakam Dinesh Pal, White Julia, Libutti Steven, Ganesan Shridar, Riedlinger Gregory M, Loughran Thomas P, Halme Dina Gould, Johns Margaret A, Arciero Cletus, Salhia Bodour, Naqash Abdul Rafeh, Shriver Craig D, Lee Kelvin P, Schneider Bryan P, Nix David A, Fillmore Gary C, Colman Howard, Ulrich Cornelia M, Springer Brian C, Pollock Raphael, Vucic Emily A, Sherman Jeff, Jain Anshu K, Dalton William S, Agius Phaedra, Siegel Erin M

СтатьяПрепринтПеревод в очереди

Аннотация

Over a decade ago, collaborating academic cancer centers formed the Oncology Research Information Exchange Network® (ORIEN) to develop a patient-driven, federated infrastructure for oncology research. Aster Insights is the network's operational, commercial, and research partner. Together ORIEN and Aster Insights have built a unique multimodal dataset on the active engagement and consent of patients who opted into the Total Cancer Care® (TCC) protocol to contribute their data and biospecimens for research. Over 400,000 cancer patients have been enrolled in TCC, >32,500 of which have an in silico "Avatar" generated to represent their individual patient experience and molecular profile to support a broad range of network and industry research use cases. We provide an overview of ORIEN's evolution, demonstrate the power of our data resources through a landmark analysis of >37,000 tumors across all cancer types collected for the Avatar program, and provide a vision for ORIEN to fuel collaborative research.

Для цитирования: Churchman Michelle L, Lu Xin, McKean David M, Radmacher Michael D, Zhang Qi, Rounbehler Robert J, Tan Aik Choon, Shaw Timothy I, Obermayer Alyssa, Grass G Daniel, Spakowicz Daniel, Tarhini Ahmad A, Shain Kenneth H, Canevarolo Rafael Renatino, Meads Mark B, Silva Ariosto S, Sudalagunta Praneeth Reddy, Manley Brandon J, Huntsman Shane, Collyar Deborah, Kolesar Jill M, Evers B Mark, Single Nancy, Edge Stephen B, Johnson Candace S, Weiner George J, McCarter Martin D, Borges Virginia F, Horne Latrisha, Lillard James W, Mudaranthakam Dinesh Pal, White Julia, Libutti Steven, Ganesan Shridar, Riedlinger Gregory M, Loughran Thomas P, Halme Dina Gould, Johns Margaret A, Arciero Cletus, Salhia Bodour, Naqash Abdul Rafeh, Shriver Craig D, Lee Kelvin P, Schneider Bryan P, Nix David A, Fillmore Gary C, Colman Howard, Ulrich Cornelia M, Springer Brian C, Pollock Raphael, Vucic Emily A, Sherman Jeff, Jain Anshu K, Dalton William S, Agius Phaedra, Siegel Erin M. The Oncology Research Information Exchange Network (ORIEN) - Building a Real-World Collaborative, Patient-driven Infrastructure for Discovery Research and Precision Oncology.. Research square. 2026. DOI: 10.21203/rs.3.rs-7077810/v1.
Подготовка и перевод публикации
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.

Тип публикации указан по данным источника. Уровень доказательности автоматически не присваивается.