Oral surgery, oral medicine, oral pathology and oral radiology · 2025
Possible link between clostridioides difficile infection and oral mucositis: insights from a large real-world dataset.
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Oyewole Stella O, Owosho Adepitan A
Аннотация
BACKGROUND: Clostridioides difficile infection (CDI), the primary cause of antibiotic-associated diarrhea in the U.S., is typically gastrointestinal but may also present with extra-intestinal features such as oral mucositis. While this association has been noted in oncology populations, its occurrence in non-oncology patients remains unexplored. This study evaluates whether adults with CDI face an elevated risk of developing oral mucositis compared to matched controls without CDI.
STUDY DESIGN: A retrospective cohort study utilizing the TriNetX real-world dataset examined patients with confirmed CDI, excluding those with prior oral mucositis, leukemia, chemotherapy or radiotherapy exposure, and other major comorbidities to reduce confounding.
RESULTS: Among matched cohorts of over 227,000 individuals, the incidence of oral mucositis within 30 days post-diagnosis was notably higher in patients with CDI compared to controls (0.035% vs. 0.015%). This translates to an absolute risk difference of 0.019% and a statistically significant two-fold increased relative risk (2.26) (P < .0001), suggesting a potential association between CDI and oral mucositis.
CONCLUSION: Although the absolute risk is low, the significant relative risk suggests that oral mucositis may be an overlooked complication of CDI in non-oncology patients. These findings underscore the importance of incorporating routine oral health assessments into the care of patients with CDI.
STUDY DESIGN: A retrospective cohort study utilizing the TriNetX real-world dataset examined patients with confirmed CDI, excluding those with prior oral mucositis, leukemia, chemotherapy or radiotherapy exposure, and other major comorbidities to reduce confounding.
RESULTS: Among matched cohorts of over 227,000 individuals, the incidence of oral mucositis within 30 days post-diagnosis was notably higher in patients with CDI compared to controls (0.035% vs. 0.015%). This translates to an absolute risk difference of 0.019% and a statistically significant two-fold increased relative risk (2.26) (P < .0001), suggesting a potential association between CDI and oral mucositis.
CONCLUSION: Although the absolute risk is low, the significant relative risk suggests that oral mucositis may be an overlooked complication of CDI in non-oncology patients. These findings underscore the importance of incorporating routine oral health assessments into the care of patients with CDI.