Nuances of Adrenal Metabolic Workup.

Adrenal function testing is recommended in all adrenal nodules 1 cm or larger with evaluation for pheochromocytoma, hyperaldosteronism, cortisol production, and androgen production as 40% of adrenal nodules are functional. Additional testing can be performed in patients with suspicious nodules by imaging. A multidisciplinary approach to evaluation and treatment of adrenal nodules is mandatory to consider the nuances involved in laboratory screening, confirmatory testing, and localization procedures.