Annals of hematology · 2025
Allogeneic transplantation for CML blast phase: Learnings over last decade from a single centre in North India.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
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Patra Pritish Chandra, Rainchwar Sujay, Singh Reema, Bhatia Niharika, Bhatnagar Sakshi, Palatty Roy J, Tikare Nakul, Panda Tribikram, Sheth Vipul Sharad, Agrawal Narendra, Halder Rohan, Bhurani Dinesh
Аннотация
Chronic myeloid leukemia in the blast phase (BP-CML) remains challenging despite advancements in tyrosine kinase inhibitors (TKIs). This study retrospectively assessed BP-CML patients who underwent allogeneic stem cell transplantation (allo-SCT) from June 2009 to December 2022. Thirty-three patients were included and the median age was 41 years, with a predominantly male cohort. Myeloablative conditioning and peripheral blood stem cells were used in the majority of the patients. The estimated 2-year overall survival (OS) was 48.3% of the cohort. Relapse occurred in 48.5% of patients, typically within 3 months post-transplant. Post-transplant TKI maintenance showed a significant association with improved OS (p-value = 0.001). The study highlights the need for early intervention and optimized post-transplant maintenance to improve outcomes.