Hepatology research : the official journal of the Japan Society of Hepatology · 2019
Secondary sclerosing cholangitis with hemobilia induced by pembrolizumab: Case report and review of published work.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Koya Yudai, Shibata Michihiko, Shinohara Nobuhiko, Nebuya Satoru, Oe Shinji, Honma Yuichi, Senju Michio, Sato Naoko, Harada Masaru
Аннотация
A 66-year-old man was admitted to our department due to cholestatic liver injury. He had received five cycles of pembrolizumab for small-cell lung cancer. Imaging showed the possibility of sclerosing cholangitis (SC) with hemobilia. Histologically, CD8+ T cells had infiltrated the biliary epithelium of the extrahepatic bile duct. We reached the diagnosis of secondary SC induced by pembrolizumab. Although we treated him with high-dose corticosteroids, laboratory data showed only a moderate response. Clinicians should recognize that immune checkpoint inhibitors can sometimes cause severe and irreversible SC.