Follicular non-Hodgkin lymphoma recurrence in an uncommon site: the lacrimal caruncle.

Recurrent follicular lymphoma in the caruncle is an exceedingly rare clinical presentation, with limited cases documented in the literature. This case describes a 58-year-old male with a history of follicular non-Hodgkin lymphoma localized solely to the left caruncle, treated with systemic R-Bendamustine chemotherapy and achieving complete remission. Two years later, the patient presented with a recurrent lesion in the same anatomical site. Clinical and radiological evaluations confirmed the recurrence, and an incisional biopsy was performed, followed by histopathological analysis that reaffirmed the diagnosis of follicular lymphoma. The patient subsequently received 16 sessions of radiotherapy. This case emphasizes the unique challenges associated with managing recurrent caruncular lymphomas, highlighting the critical role of long-term surveillance and a multidisciplinary approach. The rarity of this presentation underscores the need for further research into the pathophysiology and optimal treatment strategies for follicular lymphoma in extranodal sites such as the caruncle.