Retina (Philadelphia, Pa.) · 2026
EFFICACY AND SAFETY OF AMNIOTIC MEMBRANE TRANSPLANTATION IN VITRECTOMY FOR EXTRA-LARGE OR LONG-STANDING MACULAR HOLES: A Prospective Clinical Study.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
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Wang Qihua, Han Han, Zhang Haokun, Chen Siyue, Huang Yanming, Lei Yi, Liao Mengyu, Zhao Pinting, You Caiyun, Yan Hua
Аннотация
PURPOSE: To evaluate the efficacy and safety of amniotic membrane transplantation during vitrectomy for extra-large or long-standing macular holes (MH).
METHODS: A single-center, noncomparative prospective observational study included eight eyes from eight patients with extra-large or long-standing MHs (six recurrent, two primary). All patients underwent vitrectomy with amniotic membrane transplantation over the MH. Baseline assessments included best-corrected visual acuity, optical coherence tomography, multifocal electroretinography, macula microperimetry, and adaptive optics imaging to evaluate photoreceptor cells on the graft surface. Outcome measures were recorded during follow-up.
RESULTS: All eight eyes achieved MH closure during the follow-up period, with 1 case developing amniotic membrane graft displacement that did not cause MH recurrence. After the follow-up ended, at 18 months postoperatively, this case experienced a recurrence of the MH due to rhegmatogenous retinal detachment(mean follow-up: 14.3 ± 8.1 months). Baseline MH diameter was 825.2 ± 265.9 µ m. Best-corrected visual acuity improved in four eyes (50%) and stabilized in others. Multifocal electroretinography showed increased amplitude and shortened peak time at 1 month postoperatively, peaking at 3 months and stabilizing by 6 months. Microperimetry revealed improved retinal sensitivity in five eyes (62.5%), with enhanced 2° and 4° fixation rates. Absolute scotomas resolved posttreatment. Adaptive optics imaging confirmed photoreceptor cell attachment on the graft surface. No adverse events related to the amniotic membrane were observed.
CONCLUSION: Amniotic membrane transplantation facilitates extra-large or long-standing MH closure, improves macular function, and demonstrates favorable safety. This approach may enhance photoreceptor recovery, supporting its clinical utility.
METHODS: A single-center, noncomparative prospective observational study included eight eyes from eight patients with extra-large or long-standing MHs (six recurrent, two primary). All patients underwent vitrectomy with amniotic membrane transplantation over the MH. Baseline assessments included best-corrected visual acuity, optical coherence tomography, multifocal electroretinography, macula microperimetry, and adaptive optics imaging to evaluate photoreceptor cells on the graft surface. Outcome measures were recorded during follow-up.
RESULTS: All eight eyes achieved MH closure during the follow-up period, with 1 case developing amniotic membrane graft displacement that did not cause MH recurrence. After the follow-up ended, at 18 months postoperatively, this case experienced a recurrence of the MH due to rhegmatogenous retinal detachment(mean follow-up: 14.3 ± 8.1 months). Baseline MH diameter was 825.2 ± 265.9 µ m. Best-corrected visual acuity improved in four eyes (50%) and stabilized in others. Multifocal electroretinography showed increased amplitude and shortened peak time at 1 month postoperatively, peaking at 3 months and stabilizing by 6 months. Microperimetry revealed improved retinal sensitivity in five eyes (62.5%), with enhanced 2° and 4° fixation rates. Absolute scotomas resolved posttreatment. Adaptive optics imaging confirmed photoreceptor cell attachment on the graft surface. No adverse events related to the amniotic membrane were observed.
CONCLUSION: Amniotic membrane transplantation facilitates extra-large or long-standing MH closure, improves macular function, and demonstrates favorable safety. This approach may enhance photoreceptor recovery, supporting its clinical utility.