MedElevator Войти в исследования
← Поиск публикаций

DOI 10.1016/j.xcrm.2025.102029

Медицинская библиотека · Cell reports. Medicine · 2025

A patient-derived T cell lymphoma biorepository uncovers pathogenetic mechanisms and host-related therapeutic vulnerabilities.

Fiore Danilo, Cappelli Luca Vincenzo, Zhaoqi Liu, Kotlov Nikita, Sorokina Maria, Phillip Jude, Zumbo Paul, Yoffe Liron, Ghione Paola, Wang Anqi, Han Xueshuai, Taylor Abigail, Chiu William, Fragliasso Valentina, Tabbo Fabrizio, Zamponi Nahuel, Di Siervi Nicolás, Kayembe Clarisse, Medico Giovanni, Patel Ruchi P, Gaudiano Marcello, Machiorlatti Rodolfo, Astone Giuseppina, Cacciapuoti Maria Teresa, Zanetti Giorgia, Pignataro Claudia, Eric Ruiz Arvin, Patel Sanjay, Zammarchi Francesca, Zanettini Claudio, Queiroz Lucio, Nikitina Anastasia, Kudryashova Olga, Karelin Anton, Nikitin Daniil, Tychinin Dmitry, Postovalova Ekaterina, Bagaev Alexander, Svekolkin Viktor, Belova Ekaterina, Tikhonova Katerina, Degryse Sandrine, Xu Chengqi, Novero Domenico, Ponzoni Maurilio, Tiacci Enrico, Falini Brunangelo, Song Joo, Khodos Inna, De Stanchina Elisa, Macari Gabriele, Cafforio Luciana, Gardini Simone, Piva Roberto, Medico Enzo, Ng Samuel Y, Moskowitz Allison, Epstein Zachary, Intlekofer Andrew, Ahmed Dogan, Chan Wing C, Martin Peter, Ruan Jia, Bertoni Francesco, Foà Robin, Brody Joshua D, Weinstock David M, Osan Jaspreet, Santambrogio Laura, Elemento Oliver, Betel Doron, Tam Wayne, Ruella Marco, Cerchietti Leandro, Rabadan Raul, Horwitz Steven, Inghirami Giorgio

СтатьяПеревод в очереди

Аннотация

Peripheral T cell lymphomas (PTCLs) comprise heterogeneous malignancies with limited therapeutic options. To uncover targetable vulnerabilities, we generate a collection of PTCL patient-derived tumor xenografts (PDXs) retaining histomorphology and molecular donor-tumor features over serial xenografting. PDX demonstrates remarkable heterogeneity, complex intratumor architecture, and stepwise trajectories mimicking primary evolutions. Combining functional transcriptional stratification and multiparametric imaging, we identify four distinct PTCL microenvironment subtypes with prognostic value. Mechanistically, we discover a subset of PTCLs expressing Epstein-Barr virus-specific T cell receptors and uncover the capacity of cancer-associated fibroblasts of counteracting treatments. PDXs' pre-clinical testing captures individual vulnerabilities, mirrors donor patients' clinical responses, and defines effective patient-tailored treatments. Ultimately, we assess the efficacy of CD5KO- and CD30- Chimeric Antigen Receptor T Cells (CD5KO-CART and CD30_CART, respectively), demonstrating their therapeutic potential and the synergistic role of immune checkpoint inhibitors for PTCL treatment. This repository represents a resource for discovering and validating intrinsic and extrinsic factors and improving the selection of drugs/combinations and immune-based therapies.

Для цитирования: Fiore Danilo, Cappelli Luca Vincenzo, Zhaoqi Liu, Kotlov Nikita, Sorokina Maria, Phillip Jude, Zumbo Paul, Yoffe Liron, Ghione Paola, Wang Anqi, Han Xueshuai, Taylor Abigail, Chiu William, Fragliasso Valentina, Tabbo Fabrizio, Zamponi Nahuel, Di Siervi Nicolás, Kayembe Clarisse, Medico Giovanni, Patel Ruchi P, Gaudiano Marcello, Machiorlatti Rodolfo, Astone Giuseppina, Cacciapuoti Maria Teresa, Zanetti Giorgia, Pignataro Claudia, Eric Ruiz Arvin, Patel Sanjay, Zammarchi Francesca, Zanettini Claudio, Queiroz Lucio, Nikitina Anastasia, Kudryashova Olga, Karelin Anton, Nikitin Daniil, Tychinin Dmitry, Postovalova Ekaterina, Bagaev Alexander, Svekolkin Viktor, Belova Ekaterina, Tikhonova Katerina, Degryse Sandrine, Xu Chengqi, Novero Domenico, Ponzoni Maurilio, Tiacci Enrico, Falini Brunangelo, Song Joo, Khodos Inna, De Stanchina Elisa, Macari Gabriele, Cafforio Luciana, Gardini Simone, Piva Roberto, Medico Enzo, Ng Samuel Y, Moskowitz Allison, Epstein Zachary, Intlekofer Andrew, Ahmed Dogan, Chan Wing C, Martin Peter, Ruan Jia, Bertoni Francesco, Foà Robin, Brody Joshua D, Weinstock David M, Osan Jaspreet, Santambrogio Laura, Elemento Oliver, Betel Doron, Tam Wayne, Ruella Marco, Cerchietti Leandro, Rabadan Raul, Horwitz Steven, Inghirami Giorgio. A patient-derived T cell lymphoma biorepository uncovers pathogenetic mechanisms and host-related therapeutic vulnerabilities.. Cell reports. Medicine. 2025. DOI: 10.1016/j.xcrm.2025.102029.

Предметные рубрики MeSH

HumansAnimalsTumor MicroenvironmentLymphoma, T-Cell, PeripheralMiceXenograft Model Antitumor AssaysHerpesvirus 4, HumanMice, Inbred NODFemaleImmune Checkpoint Inhibitors
Подготовка и перевод публикации
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.

Тип публикации указан по данным источника. Уровень доказательности автоматически не присваивается.