Early Death Incidence and Prediction Among Patients With Hypopharynx Squamous Cell Carcinomas.

Background

The objective of this study is to evaluate the incidence and associated factors for early death (ED) in hypopharynx squamous cell carcinomas (SCC) patients. Materials and

Methods

Patients were extracted from the Surveillance, Epidemiology and End Results database between 2004 and 2014. The ED (survival time ≤3 months) rate was calculated, and associated risk factors were evaluated by the logistic regression models.

Results

A total of 2659 patients were analyzed and 307 (11.5%) patients died within 3 months after cancer diagnosis, among whom 243 (79.2%) patients died from cancer-specific cause. In univariate analyses, advanced age, divorced/single/widowed (DSW), non-Caucasian, advanced T classification, distant metastasis, and no surgery were significantly associated with ED (P < .05, respectively). Multivariate analyses showed that advanced age, DSW, advanced T classification, distant metastasis, and no surgery were significantly associated with all-cause and cancer-specific ED.

Conclusion

Our results showed that a total of 11.5% patients with hypopharynx SCC suffered ED, among whom 79.2% patients died from cancer-specific cause. Predictors of ED are primarily related to age ≥62 years, advanced T classification, distant metastasis, and no surgery but also include unmarried status; better prognostic and predictive tools for select ED patients in larger sample size are needed.