Dermatology (Basel, Switzerland) · 2024
Early Organ Metastasis in Granulomatous Mycosis Fungoides: A Systematic Review.
Систематический обзорСтатьяНазвание и аннотация: Перевод в очереди
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Motamedi Melika, Xiao Maggie Z X, Deschenes Jean, Hardin Jori, Sterrett Russell, Street Lesley, Taparia Minakshi, Mahe Etienne, Ferrara Giovanni, Barrie James R, Gniadecki Robert
Аннотация
BACKGROUND: Granulomatous mycosis fungoides (GMF) is a rare form of cutaneous T-cell lymphoma characterized by a granulomatous inflammatory infiltrate.
OBJECTIVE: The impact of granulomatous inflammation on the prognosis of the disease remains controversial as there have been both favorable and unfavorable outcomes documented.
METHODS: We performed a systematic review of 116 GMF cases previously described in the literature.
RESULTS: In contrast to the classic Alibert-Bazin type of mycosis fungoides (MF), cutaneous lesions in GMF tend to involve distal extremities (lower legs, feet, hands) early in the disease course. In the literature, 30% of GMF patients developed organ metastasis, most frequently to the lung. The median time to stage progression was 25 months.
CONCLUSION: GMF is an aggressive form of MF. Therefore, screening for distant metastases should be considered at presentation and repeated during follow-up.
OBJECTIVE: The impact of granulomatous inflammation on the prognosis of the disease remains controversial as there have been both favorable and unfavorable outcomes documented.
METHODS: We performed a systematic review of 116 GMF cases previously described in the literature.
RESULTS: In contrast to the classic Alibert-Bazin type of mycosis fungoides (MF), cutaneous lesions in GMF tend to involve distal extremities (lower legs, feet, hands) early in the disease course. In the literature, 30% of GMF patients developed organ metastasis, most frequently to the lung. The median time to stage progression was 25 months.
CONCLUSION: GMF is an aggressive form of MF. Therefore, screening for distant metastases should be considered at presentation and repeated during follow-up.