Cytogenetic and genome research · 2025
Jumping Translocation of 3q in a Patient with Mantle Cell Lymphoma: A Case Report and Review of the Literature.
СтатьяКлинический случайОбзорНазвание и аннотация: Перевод в очереди
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Kouvidi Elisavet, Boutsikas Georgios, Giannikos Theofanis, Kalomoiraki Marina, Haralampous Ioanna, Boulari Dimitra, Dandoulaki Maria, Roumelioti Maria, Pallaki Paschalina, Anagnostopoulos Ioannis
Аннотация
INTRODUCTION: Jumping translocations are rare cytogenetic events in hematologic malignancies, involving nonreciprocal translocation of a donor chromosome onto two or more recipient chromosomes.
CASE PRESENTATION: In this paper, we report the first-ever case of a jumping translocation involving the long arm of chromosome 3 in a patient with mantle cell lymphoma. The basic clone had the translocation t(11;14)(q13;q32) and a der(13)t(3;13)(q12;p11), and the three subclones had an additional jumping translocation, involving the translocation of 3q12 onto recipient chromosomes 14p, 15p, and der(14)t(11;14), thus resulting in partial trisomy and tetrasomy 3q.
CONCLUSION: Although the underlying mechanism for the formation of jumping translocations is not well understood, their presence is usually associated with poor prognosis and clonal evolution and additional data are needed for their better clinical management.
CASE PRESENTATION: In this paper, we report the first-ever case of a jumping translocation involving the long arm of chromosome 3 in a patient with mantle cell lymphoma. The basic clone had the translocation t(11;14)(q13;q32) and a der(13)t(3;13)(q12;p11), and the three subclones had an additional jumping translocation, involving the translocation of 3q12 onto recipient chromosomes 14p, 15p, and der(14)t(11;14), thus resulting in partial trisomy and tetrasomy 3q.
CONCLUSION: Although the underlying mechanism for the formation of jumping translocations is not well understood, their presence is usually associated with poor prognosis and clonal evolution and additional data are needed for their better clinical management.