Successful reconstruction with gastrojejunostomy and pancreaticobiliary junction anastomosis to the duodenum after duodenal peripapillary adenocarcinoma resection.

CASE SUMMARY: A 13-year-old spayed female domestic shorthair cat presented with jaundice, showing increased levels of serum liver enzymes and total bilirubin. Abdominal ultrasound revealed a tortuous, dilated common bile duct and a 5-6 mm isoechoic mass near the greater papilla in the duodenum. A CT scan revealed the presence of a duodenal mass that disrupted mucosal continuity and obstructed the common bile and pancreatic ducts. The cat underwent an excisional biopsy of the affected mucosa near the major duodenal papilla. Histopathological examination revealed adenocarcinoma, which was completely removed through duodenal resection. The pancreaticobiliary junction was then anastomosed to the afferent duodenal loop, followed by a gastrojejunostomy procedure. The postoperative total serum bilirubin and pancreatic enzyme levels were within the reference interval. The patient showed no signs of recurrence on postoperative day 408.

RELEVANCE AND NOVEL INFORMATION: This study reports the first case of duodenal peripapillary adenocarcinoma in a cat with long-term postoperative survival. After the complete peripapillary adenocarcinoma resection, a successful surgical digestive system reconstruction was conducted through gastrojejunostomy and pancreaticobiliary junction anastomosis to the duodenum. This approach shows potential as a treatment for duodenal lesions involving the major papilla in cats.