Fertility and sterility · 2012
Live birth after transplantation of frozen-thawed ovarian tissue after bilateral oophorectomy for benign disease.
Клинический случайСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Donnez Jacques, Jadoul Pascale, Pirard Céline, Hutchings Graham, Demylle Dominique, Squifflet Jean, Smitz Johan, Dolmans Marie-Madeleine
Аннотация
OBJECTIVE: To report the restoration of ovarian function and pregnancy in a woman after bilateral oophorectomy for benign disease after autotransplantation of cryopreserved ovarian cortex.
DESIGN: Case report.
SETTING: Gynecology research unit in a university hospital.
PATIENT(S): A 28-year-old woman who underwent bilateral adnexectomy for ovarian abscesses at the age of 18 years.
INTERVENTION(S): We performed ovarian cortex autotransplantation to a peritoneal pocket in the broad ligament.
MAIN OUTCOME MEASURE(S): Restoration of ovarian activity and pregnancy.
RESULT(S): Restoration of ovarian function began at 20 weeks and was achieved 24 weeks after transplantation. After the fifth stimulation attempt, two mature oocytes were obtained and microinjected. One embryo (seven cells) was obtained and transferred, leading to a normal pregnancy. The patient delivered a healthy baby boy weighing 2,370 g at 38 weeks of gestation.
CONCLUSION(S): Ovarian cortex cryopreservation can be performed at the time of surgery for benign diseases when fertility is impaired. We report the first pregnancy to occur after ovarian tissue cryopreservation for benign ovarian pathology after bilateral oophorectomy.
DESIGN: Case report.
SETTING: Gynecology research unit in a university hospital.
PATIENT(S): A 28-year-old woman who underwent bilateral adnexectomy for ovarian abscesses at the age of 18 years.
INTERVENTION(S): We performed ovarian cortex autotransplantation to a peritoneal pocket in the broad ligament.
MAIN OUTCOME MEASURE(S): Restoration of ovarian activity and pregnancy.
RESULT(S): Restoration of ovarian function began at 20 weeks and was achieved 24 weeks after transplantation. After the fifth stimulation attempt, two mature oocytes were obtained and microinjected. One embryo (seven cells) was obtained and transferred, leading to a normal pregnancy. The patient delivered a healthy baby boy weighing 2,370 g at 38 weeks of gestation.
CONCLUSION(S): Ovarian cortex cryopreservation can be performed at the time of surgery for benign diseases when fertility is impaired. We report the first pregnancy to occur after ovarian tissue cryopreservation for benign ovarian pathology after bilateral oophorectomy.