Journal of pediatric hematology/oncology · 2018
Aplastic Anemia as an Immune-mediated Complication of Thymoma: A Case Report.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Toret Ersin, Demirag Bengü, Köker Sultan A, Doyurgan Onur, Ergin Malik, Genc Sinan, Karapinar Tuba H, Ay Yilmaz, Oymak Yeşim, Vergin Canan
Аннотация
Thymomas are the most common masses located in the anterior mediastinum, and they are often associated with autoimmune disorders including myasthenia gravis, polymyositis, and aplastic anemia (AA). Autoreactive T-cell clones generated by the thymoma may lead to autoimmune disorders. We report the case of a 14-year-old boy who was examined for AA, and the underlying cause was determined to be an immune-mediated complication of thymoma. He had no matched sibling donors. He underwent thymectomy, and 3 months later he was treated with immunosuppressive therapy (IST), consisting of antithymocyte globulin and cyclosporine A. The duration of the IST was determined to be a period of 12 months. He has recently been in complete response condition for 6 months since IST stopped. IST is a successful treatment choice for thymomas associated with AA in childhood.