Academic radiology · 2025
Dual-Vessel Microcirculation Imaging in Discriminating Non-Hodgkin Lymphoma Subtypes Using Super-Resolution Ultrasound: An Exploring Study.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Dong YiJie, Hua Qing, Xia ShuJun, Yuan CongCong, Li Cheng, Song YanYan, Zheng YuHang, Tao RuoLin, Liu ZhenHua, Zhang YuLu, Wu FangGang, Guo Wei, Tian Yuan, Zhou JianQiao
Аннотация
BACKGROUND: Identifying the subtype of intranodal non-Hodgkin lymphoma (NHL) is crucial for clinical management.
RATIONALE AND OBJECTIVES: To display dual-vessel systems (microvascular and microlymphatic circulation) of intranodal NHL using super-resolution ultrasound (SRUS), and explore the diagnostic performance of SRUS imaging for predicting B-cell and T-cell subtypes NHL.
MATERIALS AND METHODS: A total of 49 patients with intranodal NHL underwent dual-vessel system SRUS imaging via intravenous and intra-lymph node routes. Least absolute shrinkage and selection operator (LASSO) regression, fitted the LASSO model and leave-one-out cross-validation (LOOCV) were used for model development and internal validation.
RESULTS: Among the 49 patients, 40 were diagnosed with B-cell NHL and 9 with T-cell NHL. Variables including LDmax, LDLmin, and VCmin were selected and the logistic regression model achieved discrimination of B-cell and T-cell subtype of lymphoma with an AUC of 0.831 (0.594-0.969).
CONCLUSION: Dual-vessel SRUS imaging can display real time microvascular and microlymphatic circulation of intranodal NHL in physiological status. With quantitative analysis of SRUS offers a potential non-invasive diagnostic alternative in differentiating NHL subtype.
RATIONALE AND OBJECTIVES: To display dual-vessel systems (microvascular and microlymphatic circulation) of intranodal NHL using super-resolution ultrasound (SRUS), and explore the diagnostic performance of SRUS imaging for predicting B-cell and T-cell subtypes NHL.
MATERIALS AND METHODS: A total of 49 patients with intranodal NHL underwent dual-vessel system SRUS imaging via intravenous and intra-lymph node routes. Least absolute shrinkage and selection operator (LASSO) regression, fitted the LASSO model and leave-one-out cross-validation (LOOCV) were used for model development and internal validation.
RESULTS: Among the 49 patients, 40 were diagnosed with B-cell NHL and 9 with T-cell NHL. Variables including LDmax, LDLmin, and VCmin were selected and the logistic regression model achieved discrimination of B-cell and T-cell subtype of lymphoma with an AUC of 0.831 (0.594-0.969).
CONCLUSION: Dual-vessel SRUS imaging can display real time microvascular and microlymphatic circulation of intranodal NHL in physiological status. With quantitative analysis of SRUS offers a potential non-invasive diagnostic alternative in differentiating NHL subtype.