Frontiers in oncology · 2026
Dosimetric comparison of MRI-guided and CT-guided intracavitary and interstitial brachytherapy for locally advanced cervical cancer.
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Yang Wencui, Lu Jun, Wang Li, Wang Haiyun, Li Peng, Zhang Qi
Аннотация
PURPOSE: To compare the differences in dosimetry and toxicities between Magnetic Resonance Imaging (MRI) and Computed Tomography (CT)-guided intracavitary and interstitial implantation for locally advanced cervical cancer, respectively.
METHODS: We analyzed 40 cases of locally advanced cervical cancer admitted to our hospital from January 2023 to September 2024. Patients underwent CT-guided intracavitary and interstitial implantation followed by MRI scanning. We compared the volume of HR-CTV and IR-CTV, the dosimetric differences of HR-CTV D90 and IR-CTV D90, and the dosimetric differences of D2cc for the bladder, rectum, and small intestine under the two localization methods.
RESULTS: The mean HR-CTV and IR-CTV volumes were larger using CT guidance compared with MRI guidance (P<0.05), the differences were statistically significant. The HR-CTV D90 and IR-CTV D90 were smaller using CT than MRI guidance. The difference was statistically significant (P<0.05). There was a statistically significant difference in the rectum D2cc between CT and MRI guidance (P<0.05), while there was no statistically significant difference for the D2cc of the bladder and small intestine between the two methods (P>0.05).
CONCLUSION: Intracavitary and interstitial implantation under MRI guidance can significantly improve HR-CTV and IR-CTV D90 with reduced target volume and good protection of the rectum, and there is no significant difference for the bladder and small intestine.
METHODS: We analyzed 40 cases of locally advanced cervical cancer admitted to our hospital from January 2023 to September 2024. Patients underwent CT-guided intracavitary and interstitial implantation followed by MRI scanning. We compared the volume of HR-CTV and IR-CTV, the dosimetric differences of HR-CTV D90 and IR-CTV D90, and the dosimetric differences of D2cc for the bladder, rectum, and small intestine under the two localization methods.
RESULTS: The mean HR-CTV and IR-CTV volumes were larger using CT guidance compared with MRI guidance (P<0.05), the differences were statistically significant. The HR-CTV D90 and IR-CTV D90 were smaller using CT than MRI guidance. The difference was statistically significant (P<0.05). There was a statistically significant difference in the rectum D2cc between CT and MRI guidance (P<0.05), while there was no statistically significant difference for the D2cc of the bladder and small intestine between the two methods (P>0.05).
CONCLUSION: Intracavitary and interstitial implantation under MRI guidance can significantly improve HR-CTV and IR-CTV D90 with reduced target volume and good protection of the rectum, and there is no significant difference for the bladder and small intestine.