Journal of the American Dental Association (1939) · 2026
Living evidence-informed guideline on the early detection of oral squamous cell carcinoma and potentially malignant disorders: Light-based adjuncts to determine the need for biopsy, Version 2026 1.0.
СтатьяКлинические рекомендацииСистематический обзорНазвание и аннотация: Перевод в очереди
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Bhosale Ankita Shashikant, Martins-Pfeifer Carolina, Verdugo-Paiva Francisca, Urquhart Olivia, Carrasco-Labra Alonso, Pimentel Julia, Kerr A Ross, Magalhaes Marco, Murdoch-Kinch Carol Anne, Gurenlian JoAnn, Agrawal Nishant, Chaturvedi Anil K, Grayzel Eva, Pearson Alexander T, Melville James C, Patel Anita S H, Villa Alessandro, Glick Michael, Lingen Mark W
Аннотация
BACKGROUND: Identifying oral potentially malignant disorders and oral cavity cancer early can lead to better patient outcomes. The guideline panel evaluated the usefulness of light-based adjuncts for screening adults without mucosal abnormalities and for determining the need for biopsy among adults with mucosal abnormalities in the oral cavity or on the lip.
TYPES OF STUDIES REVIEWED: The authors conducted a living systematic review to evaluate evidence on the benefits and harms of light-based adjuncts and a scoping review to assess people and clinician values and preferences regarding the use of light-based adjuncts and biopsy of mucosal abnormalities. The guideline panel used this evidence to formulate recommendations according to the Grading of Recommendations Assessment, Development and Evaluation Evidence to Decision framework. The framework also guided the panel's consideration of required resources, equity, acceptability, and feasibility in shaping the final recommendations.
RESULTS: The guideline panel formulated 2 recommendations and 2 good practice statements. For adults with and without mucosal abnormalities, they formulated conditional recommendations against the use of light-based adjuncts on the basis of very low certainty evidence. The good practice statements urge clinicians to perform a clinical oral examination in all adult patients.
CONCLUSIONS AND PRACTICAL IMPLICATIONS: Biopsy remains the reference standard for establishing a definitive diagnosis of an oral potentially malignant disorder and oral squamous cell carcinoma. All adults should undergo a clinical oral examination in primary care settings. When implementing or adapting these recommendations, local contexts should be considered to promote equitable access to early detection.
TYPES OF STUDIES REVIEWED: The authors conducted a living systematic review to evaluate evidence on the benefits and harms of light-based adjuncts and a scoping review to assess people and clinician values and preferences regarding the use of light-based adjuncts and biopsy of mucosal abnormalities. The guideline panel used this evidence to formulate recommendations according to the Grading of Recommendations Assessment, Development and Evaluation Evidence to Decision framework. The framework also guided the panel's consideration of required resources, equity, acceptability, and feasibility in shaping the final recommendations.
RESULTS: The guideline panel formulated 2 recommendations and 2 good practice statements. For adults with and without mucosal abnormalities, they formulated conditional recommendations against the use of light-based adjuncts on the basis of very low certainty evidence. The good practice statements urge clinicians to perform a clinical oral examination in all adult patients.
CONCLUSIONS AND PRACTICAL IMPLICATIONS: Biopsy remains the reference standard for establishing a definitive diagnosis of an oral potentially malignant disorder and oral squamous cell carcinoma. All adults should undergo a clinical oral examination in primary care settings. When implementing or adapting these recommendations, local contexts should be considered to promote equitable access to early detection.