Epilepsy research · 2026
Is temporal lobe epilepsy a progressive disease? Insights from a 5-HT1A receptor partial volume correction study.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Giovacchini Giampiero, Marciano Andrea, Agrawal Shubhi, Theodore William H
Аннотация
BACKGROUND AND OBJECTIVES: Clinical, magnetic resonance (MR) and [18F]fluorodeoxyglucose positron emission tomography (PET) studies suggest that temporal lobe epilepsy (TLE) might be a progressive disease. Whether epilepsy progression affects 5-HT1A receptor concentration is still unknown.
METHODS: We used PET with the 5-HT1A ligand [18F]FCWAY in 22 TLE patients. Dynamic frames were acquired for 120-min and modeled with a simplified 3-parameter 2-tissue compartment. An automated, MR-segmentation-based partial volume correction (PVC) algorithm was applied. Contralateral-ipsilateral asymmetry indices (AI) of the binding potential (BPF = (VT-VND)/fP) were measured and the effects of epilepsy duration and MR findings were assessed.
RESULTS: In the whole group, there was no significant (P > 0.05) correlation between epilepsy duration and AI in any region. However, in the subgroup of patients (n = 16) with mesial temporal sclerosis (MTS) a significant positive relationship between epilepsy duration and AI was found in hippocampus and parahippocampus. Patients with MTS had significantly greater hippocampus AI than patients with normal MR.
CONCLUSION: Our results further support the hypothesis that in a subset of patients epilepsy might be 'progressive' by first showing significant correlations between epilepsy duration and 5-HT1A receptor concentration in hippocampus and parahippocampus of TLE patients with MTS. Loss of 5-HT1A receptors exceeds loss of gray matter because the relationship between epilepsy duration and 5-HT1A receptor concentration persists after PVC.
METHODS: We used PET with the 5-HT1A ligand [18F]FCWAY in 22 TLE patients. Dynamic frames were acquired for 120-min and modeled with a simplified 3-parameter 2-tissue compartment. An automated, MR-segmentation-based partial volume correction (PVC) algorithm was applied. Contralateral-ipsilateral asymmetry indices (AI) of the binding potential (BPF = (VT-VND)/fP) were measured and the effects of epilepsy duration and MR findings were assessed.
RESULTS: In the whole group, there was no significant (P > 0.05) correlation between epilepsy duration and AI in any region. However, in the subgroup of patients (n = 16) with mesial temporal sclerosis (MTS) a significant positive relationship between epilepsy duration and AI was found in hippocampus and parahippocampus. Patients with MTS had significantly greater hippocampus AI than patients with normal MR.
CONCLUSION: Our results further support the hypothesis that in a subset of patients epilepsy might be 'progressive' by first showing significant correlations between epilepsy duration and 5-HT1A receptor concentration in hippocampus and parahippocampus of TLE patients with MTS. Loss of 5-HT1A receptors exceeds loss of gray matter because the relationship between epilepsy duration and 5-HT1A receptor concentration persists after PVC.