Adherence to the Mediterranean diet and risk of pancreatic cancer: an analysis of 2.3 million participants in the Pooling Project of Prospective Studies of Diet and Cancer (DCPP).
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Shen Qinting, Mobley Claire, Wang Molin, Ferrari Pietro, Adami Hans-Olov, Afshar Nina, Babic Ana, van den Brandt Piet A, Cheng En, Eliassen A Heather, Fung Teresa T, Giovannucci Edward L, Hirabayashi Mayo, Hou Tao, Huang Brian Z, Huang Wen-Yi, Joshu Corinne E, Kanehara Rieko, Katzke Verena, Lacey James V, Landry Matthew J, Larsson Susanna C, Liao Linda M, Martinez Maria Elena, McCullough Marjorie L, Miller Anthony B, Milne Roger L, Moore Steven C, Mucci Lorelei A, Naudin Sabine, Prizment Anna, Park Song-Yi, Rohan Thomas E, Riboli Elio, Robien Kim, Sandin Sven, Sawada Norie, Shams-White Marissa M, Sinha Rashmi, Smith-Byrne Karl, Stampfer Meir J, Stolzenberg-Solomon Rachael Z, Um Caroline Y, Visvanathan Kala, Wang Sophia S, Weiderpass Elisabete, White Emily, Willett Walter C, Wolk Alicja, Wolpin Brian M, Yuan Chen, Smith-Warner Stephanie A, Genkinger Jeanine M
Аннотация
Pancreatic cancer incidence is rising, yet few modifiable risk factors have been identified. The Mediterranean diet, which lowers inflammation and improves healthy weight maintenance and insulin control, may lower pancreatic cancer risk, yet the evidence for this association is inconsistent. To investigate the association, we conducted a pooled analysis of 2,315,406 individuals from 23 prospective cohorts in the Pooling Project of Prospective Studies of Diet and Cancer (DCPP), of whom 10,748 developed incident pancreatic cancer over a mean follow-up duration ranging from 8.1 to 23.3 years across studies. Adherence to the Mediterranean diet was assessed using the alternative Mediterranean diet score (aMED) and a modified score excluding alcohol (maMED). Study- and sex-specific hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox proportional hazards models and then pooled using random effect models. No statistically significant association was found between aMED or maMED and pancreatic cancer or pancreatic ductal adenocarcinoma (PDAC) risk. For aMED, the pooled pancreatic cancer HR was 0.96 (95% CI: 0.90-1.02) comparing the fourth to the first quartile, 0.94 (0.88-1.00) comparing high (6-9) versus low (0-3) scores, and 0.98 (0.96-1.00) per 2-unit increment in the score. Overall, there was no evidence of heterogeneity in these associations by sex, attained age, race, BMI, physical activity, or follow-up time; a positive association between maMED and pancreatic cancer risk was observed in past smokers (HR = 1.04, 95% CI 1.00-1.09) but not in never or current smokers (Pinteraction=0.04). In conclusion, there was little evidence of an association between a Mediterranean diet score and pancreatic cancer risk in this large international pooled analysis.