Cornea · 2026
Ethanol-Preserved Corneoscleral Tissue for Emergency Tectonic Keratoplasty in Corneal Perforations: A Retrospective Clinical Study.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
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Bonatti Paolo, Palme Christoph, Kremser Barnabas, Franchi Alexander, Franz Nadja, Stöckl Victoria, Oberauer Iris, Rehak Matus, Steger Bernhard
Аннотация
PURPOSE: There is a global shortage of donor tissue for corneal transplantation. Long-term stored ethanol-preserved corneoscleral tissue may help address this shortage, particularly in emergency cases of corneal perforation.
METHODS: This retrospective study analyzed tectonic keratoplasties for perforated corneal ulcers performed between January 2018 and December 2022. A total of 20 surgeries in 14 patients (6 female, 8 male) using ethanol-conserved corneoscleral tissue were included. Surgical, postoperative, and follow-up data were analyzed until December 2024, including graft storage duration, epithelialization, graft survival, complications, and best-corrected visual acuity. Outcomes were considered favorable if only planned surgery or no further surgery was required, and unfavorable if additional emergency intervention was necessary.
RESULTS: The mean patient age was 83.5 (interquartile range 69.2-87.8) years (range 40.2-89.8). The cause of corneal perforation included immune-mediated corneal ulcers n = 8 (40%), neurotrophic corneal ulcers n = 7 (35%), herpetic corneal ulcerations n = 4 (20%), and fungal keratitis n = 1 (5%). The median graft size was 4.0 mm, with a median storage duration of 71.5 days (range 4-346). Graft survival resulted to 23.2 ± 17.4 months. A favorable outcome was achieved in 12 cases (60%). Epithelial closure was observed in all cases within 15 days. Best-corrected visual acuity improved from 1.7 ± 0.8 logMAR to 1.1 ± 0.7 logMAR.
CONCLUSIONS: Ethanol-preserved corneoscleral tissue is safe and feasible for emergency tectonic keratoplasty. Its extended storage capacity may aid in the current global shortage of donor corneas.
METHODS: This retrospective study analyzed tectonic keratoplasties for perforated corneal ulcers performed between January 2018 and December 2022. A total of 20 surgeries in 14 patients (6 female, 8 male) using ethanol-conserved corneoscleral tissue were included. Surgical, postoperative, and follow-up data were analyzed until December 2024, including graft storage duration, epithelialization, graft survival, complications, and best-corrected visual acuity. Outcomes were considered favorable if only planned surgery or no further surgery was required, and unfavorable if additional emergency intervention was necessary.
RESULTS: The mean patient age was 83.5 (interquartile range 69.2-87.8) years (range 40.2-89.8). The cause of corneal perforation included immune-mediated corneal ulcers n = 8 (40%), neurotrophic corneal ulcers n = 7 (35%), herpetic corneal ulcerations n = 4 (20%), and fungal keratitis n = 1 (5%). The median graft size was 4.0 mm, with a median storage duration of 71.5 days (range 4-346). Graft survival resulted to 23.2 ± 17.4 months. A favorable outcome was achieved in 12 cases (60%). Epithelial closure was observed in all cases within 15 days. Best-corrected visual acuity improved from 1.7 ± 0.8 logMAR to 1.1 ± 0.7 logMAR.
CONCLUSIONS: Ethanol-preserved corneoscleral tissue is safe and feasible for emergency tectonic keratoplasty. Its extended storage capacity may aid in the current global shortage of donor corneas.