Journal of clinical pathology · 2013
Epithelial-mesenchymal transition phenotypes are associated with patient survival in intrahepatic cholangiocarcinoma.
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Gu Mi Jin, Choi Joon Hyuk
Аннотация
BACKGROUND: The aim of this study was to evaluate the epithelial-mesenchymal transition (EMT) and to assess its prognostic significance in intrahepatic cholangiocarcinoma.
METHODS: We performed immunohistochemical stainings for E-cadherin, β-catenin, vimentin and fibronectin in a total of 85 cases.
RESULTS: Expression of vimentin and reduced expression of E-cadherin were found to show correlation with poor differentiation (p=0.017, p=0.010). Reduced expression of β-catenin showed significant association with poor differentiation (p=0.023), tumour size (p=0.028) and lymph node metastasis (p=0.011). According to the expression pattern of E-cadherin, β-catenin, vimentin and fibronectin we categorised four phenotypes: complete type, hybrid type, null type and wild type. The complete type of β-catenin with vimentin or fibronectin was found to show an association with lymph node metastasis (p=0.048, p=0.012). Significantly worse overall survival (OS) and disease-free survival (DFS) was observed for the complete type, and the best OS and DFS were observed for the wild type.
CONCLUSIONS: EMT phenotypes can be useful markers for prediction of patient outcomes.
METHODS: We performed immunohistochemical stainings for E-cadherin, β-catenin, vimentin and fibronectin in a total of 85 cases.
RESULTS: Expression of vimentin and reduced expression of E-cadherin were found to show correlation with poor differentiation (p=0.017, p=0.010). Reduced expression of β-catenin showed significant association with poor differentiation (p=0.023), tumour size (p=0.028) and lymph node metastasis (p=0.011). According to the expression pattern of E-cadherin, β-catenin, vimentin and fibronectin we categorised four phenotypes: complete type, hybrid type, null type and wild type. The complete type of β-catenin with vimentin or fibronectin was found to show an association with lymph node metastasis (p=0.048, p=0.012). Significantly worse overall survival (OS) and disease-free survival (DFS) was observed for the complete type, and the best OS and DFS were observed for the wild type.
CONCLUSIONS: EMT phenotypes can be useful markers for prediction of patient outcomes.
Предметные рубрики MeSH
AdultAgedBile Duct NeoplasmsBile Ducts, IntrahepaticBiomarkers, TumorCholangiocarcinomaDisease ProgressionDisease-Free SurvivalEpithelial-Mesenchymal TransitionFemaleHumansImmunohistochemistryKaplan-Meier EstimateLiver NeoplasmsLymphatic MetastasisMaleMiddle AgedNeoplasm StagingPhenotypePredictive Value of TestsTime Factors