Photodiagnosis and photodynamic therapy · 2026
Comparison of 5-aminolevulinic acid-induced hypotension of extending the oral administration period during photodynamic diagnosis-assisted transurethral resection of bladder tumor for non-muscle invasive bladder cancer.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Fukuhara Hideo, Shigehisa Ryu, Yamamoto Shinkuro, Fukata Satoshi, Saito Kenta, Kamiya Atsuko, Shibanaka Yasuhiko, Koga Kunihiko, Inoue Keiji
Аннотация
BACKGROUND: Transurethral resection of bladder tumor (TURBT) using photodynamic diagnosis (PDD) with 5-aminolevulinic acid hydrochloride (5-ALA) to treat non-muscle-invasive bladder cancer (NMIBC) frequently results in hypotension being reported as a serious side effect. After this method had been approved for oral administration 2-8 hours (h) prior to cystoscope insertion in September 2024, no reports thoroughly investigated hypotension occurring with newly approved 5-ALA administration timing.
METHODS: We retrospectively compared the systolic blood pressure (SBP) values with the frequency of vasopressors between the 5-ALA exposure time 2-4 h group and that of 4-8 h group. Multivariable logistic regression analyses between them were performed for patients with (1) SBP <80 mmHg using vasopressors, and (2) treatment with vasopressors for >60 min.
RESULTS: The final analysis investigated 395 patients who underwent PDD-TURBT. The incidence of hypotension was 57.7% in the 5-ALA exposure time 2-4 h group and 40.4% in that of 4-8 h group (p = 0.002). The mean intraoperative lowest SBP was 78.7 mmHg in the 5-ALA exposure time 2-4 h group and 84.5 mmHg in that of 4-8 h group (p = 0.002). Our multivariate analyses identified risk factors for 5-ALA-induced hypotension.
CONCLUSIONS: We showed that the risk factors for 5-ALA-induced hypotension differ depending on the timing of 5-ALA administration, and that the 5-ALA exposure time 4-8 h may reduce the risk compared to that of 2-4 h. Furthermore, it became clear that careful consideration is necessary when using 5-ALA, recognizing the differences in risks in clinical use.
METHODS: We retrospectively compared the systolic blood pressure (SBP) values with the frequency of vasopressors between the 5-ALA exposure time 2-4 h group and that of 4-8 h group. Multivariable logistic regression analyses between them were performed for patients with (1) SBP <80 mmHg using vasopressors, and (2) treatment with vasopressors for >60 min.
RESULTS: The final analysis investigated 395 patients who underwent PDD-TURBT. The incidence of hypotension was 57.7% in the 5-ALA exposure time 2-4 h group and 40.4% in that of 4-8 h group (p = 0.002). The mean intraoperative lowest SBP was 78.7 mmHg in the 5-ALA exposure time 2-4 h group and 84.5 mmHg in that of 4-8 h group (p = 0.002). Our multivariate analyses identified risk factors for 5-ALA-induced hypotension.
CONCLUSIONS: We showed that the risk factors for 5-ALA-induced hypotension differ depending on the timing of 5-ALA administration, and that the 5-ALA exposure time 4-8 h may reduce the risk compared to that of 2-4 h. Furthermore, it became clear that careful consideration is necessary when using 5-ALA, recognizing the differences in risks in clinical use.