Asian journal of urology · 2025
Comparative analysis of renal parenchymal thickness and hydronephrosis: A technetium-99m dimercaptosuccinic acid single-photon emission CT and ultrasonography study.
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Sadeghi Maryam, Pak Neda, Nazari Mostafa, Ganjaroudi Negar Mohammadi, Ebrahimi Marzieh, Ahmadi Mahboobeh, Yavari Shima, Kajbafzadeh Abdol-Mohammad, Paymani Zeinab
Аннотация
OBJECTIVE: To explore a functional anteroposterior pelvis diameter (APD) cutoff for diagnosing hydronephrosis (HDN) in the pediatric population, and to evaluate the correlation between structural and functional renal parenchymal thickness (PT) measured by ultrasonography (US) and technetium-99m dimercaptosuccinic acid single-photon emission CT (99mTc-DMSA SPECT), respectively.
METHODS: This single-center cohort study enrolled 76 pediatric patients (152 kidney units) referred to the Department of Nuclear Medicine of Children's Medical Center. Structural and functional PT were measured by US and 99mTc-DMSA SPECT, respectively. The 99mTc-DMSA SPECT was assessed by a pediatric nuclear medicine specialist blinded to the US findings. The 99mTc-DMSA SPECT and US were performed on the same day. The correlation between structural and functional PT measurements was evaluated through the Spearman correlation analysis while the functional APD cutoff for HDN diagnosis was established by using the receiver operating characteristic curve.
RESULTS: The study demonstrated a poor to moderate relationship between structural and functional PT (Spearman's rho=0.30-0.52, p<0.05). A functional APD cutoff of 14 mm in the 99mTc-DMSA SPECT was in concordance with the ultrasonographic cutoff of 10 mm for diagnosing HDN.
CONCLUSION: This study can give the experts new insights into using the 99mTc-DMSA SPECT as an additional modality in measuring the functional renal dimensions, especially PT alongside the US findings.
METHODS: This single-center cohort study enrolled 76 pediatric patients (152 kidney units) referred to the Department of Nuclear Medicine of Children's Medical Center. Structural and functional PT were measured by US and 99mTc-DMSA SPECT, respectively. The 99mTc-DMSA SPECT was assessed by a pediatric nuclear medicine specialist blinded to the US findings. The 99mTc-DMSA SPECT and US were performed on the same day. The correlation between structural and functional PT measurements was evaluated through the Spearman correlation analysis while the functional APD cutoff for HDN diagnosis was established by using the receiver operating characteristic curve.
RESULTS: The study demonstrated a poor to moderate relationship between structural and functional PT (Spearman's rho=0.30-0.52, p<0.05). A functional APD cutoff of 14 mm in the 99mTc-DMSA SPECT was in concordance with the ultrasonographic cutoff of 10 mm for diagnosing HDN.
CONCLUSION: This study can give the experts new insights into using the 99mTc-DMSA SPECT as an additional modality in measuring the functional renal dimensions, especially PT alongside the US findings.