The Journal of surgical research · 2025
Clinical Outcomes of Lobectomy for Papillary Thyroid Cancer Patients With Intermediate-Risk Features.
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Wang Wenwen, Ye Ziyang, Li Genpeng, Wei Tao, Zhu Jingqiang, Li Zhihui, Tang Huairong, Lei Jianyong
Аннотация
INTRODUCTION: Lobectomy (LT) is not generally recommended for papillary thyroid cancer (PTC) patients with intermediate-risk features, although there is no high-level evidence showing that this approach is inferior. This study aimed to examine the association between the extent of thyroidectomy and the outcomes of intermediate-risk PTC patients.
METHODS: Using the Surveillance, Epidemiology, and End Results database data (2004-2020), 8543 intermediate-risk PTC patients were stratified into LT and total thyroidectomy (TT) groups. Propensity score matching generated 1557 matched pairs. Cancer-specific survival (CSS) was analyzed via Kaplan-Meier and Cox regression.
RESULTS: No significant CSS difference emerged between LT and TT in original (hazard ratio [HR] = 0.76, 95% confidence interval [CI] = 0.82-3.74, P = 0.144) or propensity score matching cohorts. Subgroup analyses confirmed comparable CSS for patients aged ≥55 y (HR = 1.55, 95% CI = 0.64-3.78, P = 0.327), tumors >40 mm (HR = 5.24, 95% CI = 0.69-39.87, P = 0.074), and lymph node metastasis (HR = 1.15, 95% CI = 0.42-3.09, P = 0.788).
CONCLUSIONS: TT was not associated with a CSS advantage for PTC patients with intermediate-risk features.
METHODS: Using the Surveillance, Epidemiology, and End Results database data (2004-2020), 8543 intermediate-risk PTC patients were stratified into LT and total thyroidectomy (TT) groups. Propensity score matching generated 1557 matched pairs. Cancer-specific survival (CSS) was analyzed via Kaplan-Meier and Cox regression.
RESULTS: No significant CSS difference emerged between LT and TT in original (hazard ratio [HR] = 0.76, 95% confidence interval [CI] = 0.82-3.74, P = 0.144) or propensity score matching cohorts. Subgroup analyses confirmed comparable CSS for patients aged ≥55 y (HR = 1.55, 95% CI = 0.64-3.78, P = 0.327), tumors >40 mm (HR = 5.24, 95% CI = 0.69-39.87, P = 0.074), and lymph node metastasis (HR = 1.15, 95% CI = 0.42-3.09, P = 0.788).
CONCLUSIONS: TT was not associated with a CSS advantage for PTC patients with intermediate-risk features.