American journal of clinical pathology · 2026
Optic nerve sheath meningiomas harbor distinct genetic variants.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Hulbert Samuel W, Lopez Gianluca, Chen Liam, Chen Suping, Pallavajjala Aparna, Haley Lisa, Nelson Aaron J Z, Maniar Arpita, Kazim Michael, Sullivan Timothy, Eberhart Charles G, Rodriguez Fausto J, Miller Neil R
Аннотация
OBJECTIVE: Both primary optic nerve sheath meningiomas (pONSMs) and secondary optic nerve sheath meningiomas (sONSMs) pose clinical challenges because standard treatments such as surgical debulking and radiation therapy can further damage the optic nerve, producing permanent visual loss. The molecular pathology of primary skull base meningiomas is becoming clearer. However, by comparison, pONSMs and sONSMs have not been studied adequately with contemporary high-throughput molecular genetic techniques, which is the primary aim of this study. This is a crucial issue because these tumors may harbor distinct genetic alterations that render them susceptible to targeted therapy, allowing for vision preservation or even visual improvement.
METHODS: A total of 18 optic nerve sheath meningiomas, of which 11 were pONSMs and 7 were sONSMs, were obtained from 3 different institutions and underwent next-generation sequencing.
RESULTS: We found that pONSMs and sONSMs harbor gene variants previously identified in other meningiomas but also distinct alterations in genes implicated in cell signaling, transcriptional regulation, and DNA damage repair.
CONCLUSIONS: These findings expand our understanding of a relatively understudied specific meningioma with unique therapeutic challenges.
METHODS: A total of 18 optic nerve sheath meningiomas, of which 11 were pONSMs and 7 were sONSMs, were obtained from 3 different institutions and underwent next-generation sequencing.
RESULTS: We found that pONSMs and sONSMs harbor gene variants previously identified in other meningiomas but also distinct alterations in genes implicated in cell signaling, transcriptional regulation, and DNA damage repair.
CONCLUSIONS: These findings expand our understanding of a relatively understudied specific meningioma with unique therapeutic challenges.