International ophthalmology · 2025
The urinary 6-sulfatoxymelatonin level in patients with central serous chorioretinopathy and its correlation with choroidal vasculature.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Xu Kun, Xu Yue, Luo Zhonghua, Shu Qinmeng, Li Lingyi, Lin Jicheng, Yang Fengmei, Tsui Ching-Kit, Tang Xiaoyu, Wu Peiqi, Kong Haolin, Yu Shanshan, Liang Xiaoling
Аннотация
PURPOSE: To investigate the changes in melatonin secretion levels and its association with choroidal vasculature parameters in patients with central serous chorioretinopathy (CSC).
METHODS: In this study, 30 male patients were enrolled diagnosed with CSC and 30 healthy male controls. The choroidal vasculature system of all participants were assessed using ultra-widefield swept-source optical coherence tomography angiography (UWF-SS-OCTA). Specifically, we measured choroidal vascular volume (CVV), choroidal vascularity index (CVI), and choroidal thickness (CT). Additionally, the levels of urinary 6-sulfatoxymelatonin(6-SMT) in participants were determined using enzyme-linked immunosorbent assay. Finally, the correlations between normalized 6-SMT and choroidal vascular parameters were evaluated in CSC and controls.
RESULTS: The levels of urinary normalized 6-SMT in CSC patients (24.8, 20.2 - 28.1) were significantly lower than the control group (36.1, 30.0 - 45.2, P < 0.001). Compared with the control group, CSC patients exhibited significantly larger average CVV, CVI, and CT (CVV: 44.6 ± 8.9 mm3 vs 38.2 ± 9.4 mm3, P < 0.01; CVI: 34.7% ± 1.8% vs 33.3% ± 3.0%, P = 0.03; CT: 242.2 ± 48.0 μm vs 207.2 ± 48.3 μm, P = 0.01). In all regions, negative correlations were found between normalized 6-SMT and CVV (maximum r-value was - 0.60, P < 0.0001), CVI (maximum r-value was - 0.57, P < 0.0001), and CT (maximum r-value was - 0.59, P < 0.0001) in all CSC and controls. Linear regression analysis showed that normalized 6-SMT was the only predictor of CVV, CVI, and CT (P < 0.05) in CSC patients.
CONCLUSION: This study found that CSC patients had lower levels of urinary 6-SMT. The concentration of 6-SMT was associated with choroidal vasculature parameters. The decrease in melatonin secretion might be a risk factor for CSC.
METHODS: In this study, 30 male patients were enrolled diagnosed with CSC and 30 healthy male controls. The choroidal vasculature system of all participants were assessed using ultra-widefield swept-source optical coherence tomography angiography (UWF-SS-OCTA). Specifically, we measured choroidal vascular volume (CVV), choroidal vascularity index (CVI), and choroidal thickness (CT). Additionally, the levels of urinary 6-sulfatoxymelatonin(6-SMT) in participants were determined using enzyme-linked immunosorbent assay. Finally, the correlations between normalized 6-SMT and choroidal vascular parameters were evaluated in CSC and controls.
RESULTS: The levels of urinary normalized 6-SMT in CSC patients (24.8, 20.2 - 28.1) were significantly lower than the control group (36.1, 30.0 - 45.2, P < 0.001). Compared with the control group, CSC patients exhibited significantly larger average CVV, CVI, and CT (CVV: 44.6 ± 8.9 mm3 vs 38.2 ± 9.4 mm3, P < 0.01; CVI: 34.7% ± 1.8% vs 33.3% ± 3.0%, P = 0.03; CT: 242.2 ± 48.0 μm vs 207.2 ± 48.3 μm, P = 0.01). In all regions, negative correlations were found between normalized 6-SMT and CVV (maximum r-value was - 0.60, P < 0.0001), CVI (maximum r-value was - 0.57, P < 0.0001), and CT (maximum r-value was - 0.59, P < 0.0001) in all CSC and controls. Linear regression analysis showed that normalized 6-SMT was the only predictor of CVV, CVI, and CT (P < 0.05) in CSC patients.
CONCLUSION: This study found that CSC patients had lower levels of urinary 6-SMT. The concentration of 6-SMT was associated with choroidal vasculature parameters. The decrease in melatonin secretion might be a risk factor for CSC.