Reproductive organ involvement in women undergoing radical cystectomy for urothelial bladder cancer: a nationwide multicenter study.
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История · было → стало
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Kato Minoru, Taoka Rikiya, Miki Jun, Saito Ryoichi, Fukuokaya Wataru, Matsui Yoshiyuki, Yamamoto Shoma, Matsue Taisuke, Hatakeyama Shingo, Kawahara Takashi, Matsuda Ayumu, Kawai Taketo, Sazuka Tomokazu, Sano Takeshi, Urabe Fumihiko, Kashima Soki, Naito Hirohito, Murakami Yoji, Miyake Makito, Daizumoto Kei, Matsushita Yuto, Hayashi Takuji, Inokuchi Junichi, Sugino Yusuke, Shiga Kenichiro, Yamaguchi Noriya, Yamamoto Shingo, Yasue Keiji, Abe Takashige, Nakanishi Shotaro, Hashine Katsuyoshi, Fujii Masato, Nishihara Kiyoaki, Matsumoto Hiroaki, Tatarano Shuichi, Wada Koichiro, Sekito Sho, Maruyama Ryo, Nishiyama Naotaka, Nishiyama Hiroyuki, Kitamura Hiroshi, Uchida Junji, Japan Urological Oncology Group
Аннотация
METHODS: A total of 2674 patients with bladder cancer were retrospectively reviewed, having undergone cystectomy at this nationwide multicenter from January 2013 to December 2019. We evaluated the incidence of malignancy in reproductive organs in a cohort of 417 women and analyzed the clinicopathological features of reproductive organ involvement. Recurrence-free survival and overall survival were reported using Kaplan-Meier survival curves.
RESULTS: Median follow-up was 36.9 months. Of the 417 patients with urothelial carcinoma of the bladder, 325 underwent hysterectomy, and 92 had a spared uterus and anterior wall of the vagina. Twenty-nine (8.9%) patients exhibited reproductive organ involvement; this consisted of 22 (6.8%) uteri, 16 (4.9%) vaginas, and two (0.6%) ovaries. Incidental primary reproductive malignancies were found in only two (0.6%) patients. Recurrence-free survival and overall survival were significantly shorter in patients with reproductive organ involvement than in those without. Patients with reproductive organ involvement were more likely to have tumors with ≥ cT3 or sub-localization at the posterior/trigone/bladder neck.
CONCLUSIONS: The risk of reproductive organ involvement cannot be ignored in women undergoing radical cystectomy for urothelial carcinoma of the bladder, therefore, the eligibility criteria for reproductive organ preservation should be considered carefully.