American journal of ophthalmology · 2026
Reticular Pseudodrusen Subtypes and Their Interaction With Soft Drusen: Longitudinal Structure-Function Analysis.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Kim Minjeong, Park Youngjoo, Choi Seung Woo, Lee Eun Kyoung, Park Un Chul, Park Kyu Hyung, Yoon Chang Ki
Аннотация
PURPOSE: To evaluate longitudinal structure-function relationships of reticular pseudodrusen (RPD) subtypes and their interaction with soft drusen (SD) on retinal sensitivity (RS) in intermediate age-related macular degeneration (AMD).
DESIGN: Retrospective cohort study.
SUBJECTS: Forty-six eyes of 28 patients diagnosed with intermediate AMD or RPD who underwent microperimetry at two time points 6 to 12 months apart.
METHODS: RPD presence and subtype (dot or ribbon) and SD were assessed individually at each of 37 Early Treatment Diabetic Retinopathy Study grid test points on co-registered multimodal imaging. Linear mixed-effects models estimated baseline RS and its change by drusen composition, with test-point location as a fixed effect and adjustment for clinical covariates, plus baseline RS for the change analysis.
MAIN OUTCOME MEASURES: Change in RS over follow-up and baseline RS, according to drusen composition.
RESULTS: At baseline, ribbon-type RPD regions showed lower RS than lesion-free regions (mean difference 0.72 ± 0.24 dB, P = .002), whereas dot-type RPD did not differ (P = .120); SD was independently associated with reduced RS (P = .021). No baseline RPD subtype × SD interaction was observed. Longitudinally, a significant interaction was found (P = .005): regions with both ribbon-type RPD and SD showed the greatest RS decline, whereas RPD subtypes did not differ without SD (all P > .9).
CONCLUSIONS: The functional impact of RPD varies by subtype and coexistence with SD. Ribbon-type RPD is associated with greater RS impairment, particularly when combined with SD, highlighting the importance of lesion phenotype in functional risk assessment.
DESIGN: Retrospective cohort study.
SUBJECTS: Forty-six eyes of 28 patients diagnosed with intermediate AMD or RPD who underwent microperimetry at two time points 6 to 12 months apart.
METHODS: RPD presence and subtype (dot or ribbon) and SD were assessed individually at each of 37 Early Treatment Diabetic Retinopathy Study grid test points on co-registered multimodal imaging. Linear mixed-effects models estimated baseline RS and its change by drusen composition, with test-point location as a fixed effect and adjustment for clinical covariates, plus baseline RS for the change analysis.
MAIN OUTCOME MEASURES: Change in RS over follow-up and baseline RS, according to drusen composition.
RESULTS: At baseline, ribbon-type RPD regions showed lower RS than lesion-free regions (mean difference 0.72 ± 0.24 dB, P = .002), whereas dot-type RPD did not differ (P = .120); SD was independently associated with reduced RS (P = .021). No baseline RPD subtype × SD interaction was observed. Longitudinally, a significant interaction was found (P = .005): regions with both ribbon-type RPD and SD showed the greatest RS decline, whereas RPD subtypes did not differ without SD (all P > .9).
CONCLUSIONS: The functional impact of RPD varies by subtype and coexistence with SD. Ribbon-type RPD is associated with greater RS impairment, particularly when combined with SD, highlighting the importance of lesion phenotype in functional risk assessment.