Cytopathology : official journal of the British Society for Clinical Cytology · 2026
The Diagnostic Yield of Fine Needle Aspiration and Biopsy Needles According to Needle Passes Number in Diagnosing Pancreatic Adenocarcinoma.
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Sbeit Wisam, Farraj Moaad, Khoury Tawfik
Аннотация
INTRODUCTION: Endoscopic ultrasound guided fine needle aspiration/biopsy (EUS-FNA/FNB) is the main diagnostic tool for solid pancreatic lesions. However, it is associated with a limited diagnostic yield.
AIM: We aimed to assess the optimal needle passes number of FNA\FNB needles to achieve maximum diagnostic yield.
METHODS: We performed a retrospective study including all patients who were diagnosed with pancreatic adenocarcinoma by EUS-FNA/FNB. The diagnostic yield was reported for all needles according to the number of needle passes.
RESULTS: Overall, 227 patients underwent EUS-FNA/FNB. FNBs in 85 patients (37.4%), and FNA in 142 patients (62.5%). The needle number passes in the FNB was 1.46 ± 0.70 versus 2.11 ± 1.12 in the FNA group (p < 0.0001). One, two, and three needle passes yielded a diagnosis rate of malignancy in 76.8%, 68.4% and 70% of cases respectively for histology, while for cytology, the yield was 78.6%, 89.4% and 100%, respectively. For FNB needle types, the acquire needle outperformed the other needle, as the histological yield for one pass was 78.6%, 80% for two passes, and 57.1% for three passes, while for cytology, the yield was 79.3%, 90%, and 100% for one, two and three passes, respectively. For the FNA needle, the cytological yield was 88.7% for one pass, and higher for two and three passes.
CONCLUSION: The number of needle passes for FNB (maximum three passes) was lower than FNA needles (3-4 passes) to obtain an optimal diagnostic yield.
AIM: We aimed to assess the optimal needle passes number of FNA\FNB needles to achieve maximum diagnostic yield.
METHODS: We performed a retrospective study including all patients who were diagnosed with pancreatic adenocarcinoma by EUS-FNA/FNB. The diagnostic yield was reported for all needles according to the number of needle passes.
RESULTS: Overall, 227 patients underwent EUS-FNA/FNB. FNBs in 85 patients (37.4%), and FNA in 142 patients (62.5%). The needle number passes in the FNB was 1.46 ± 0.70 versus 2.11 ± 1.12 in the FNA group (p < 0.0001). One, two, and three needle passes yielded a diagnosis rate of malignancy in 76.8%, 68.4% and 70% of cases respectively for histology, while for cytology, the yield was 78.6%, 89.4% and 100%, respectively. For FNB needle types, the acquire needle outperformed the other needle, as the histological yield for one pass was 78.6%, 80% for two passes, and 57.1% for three passes, while for cytology, the yield was 79.3%, 90%, and 100% for one, two and three passes, respectively. For the FNA needle, the cytological yield was 88.7% for one pass, and higher for two and three passes.
CONCLUSION: The number of needle passes for FNB (maximum three passes) was lower than FNA needles (3-4 passes) to obtain an optimal diagnostic yield.