Lactate Dehydrogenase B Expression in Cerebellum of Adult Ube3a m-/p+ Mice.

Angelman syndrome (AS) is a neurodevelopmental disorder caused by the loss of the maternal allele of the UBE3A gene, which encodes a protein essential for ubiquitin-mediated protein degradation. AS mouse models exhibit elevated lactate and acetate levels and increased Ldha gene expression in fibroblasts. We hypothesize that maternal Ube3a loss alters the protein levels of Ldha, Ldhb, Mct2, and Mct1, contributing to elevated brain lactate levels. Western blot analysis of the cerebellum from adult Ube3a m-/p+ AS and wild-type mice reveals significant sex- and genotype-specific differences in Ldhb expression. Loss of Ube3a alters the expression of Ldhb in the cerebellum.