Journal of the American College of Emergency Physicians open · 2026
Evaluating the Whole Blood Survival Advantage: How Citrate and Calcium Levels Drive Mortality in a Translational Swine Model of Polytrauma.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Rall Jason M, Nowadly Craig D, Choi Jae-Hyek, Sundermann Heang, Sutton Kaysie, Arana Allyson A, Norouzi Dena, Paredes R Madelaine, Maddry Joseph K
Аннотация
OBJECTIVES: Whole blood (WB) is increasingly used for trauma resuscitation, but clinical comparisons with component therapy (COMP) have reported mixed survival results, and physiologic contributors to any differences remain incompletely defined. We evaluated the association between excess citrate exposure, calcium (Ca2+) supplementation, hemodynamic stability, and survival during massive transfusion.
METHODS: In a randomized swine (Sus scrofa) polytrauma model, 32 castrated male and nonpregnant females underwent tibial fracture, blunt liver injury, 30% controlled hemorrhage, and a 30-minute shock period. Animals were assigned to WB without Ca2+ supplementation (WB/-Ca), WB with Ca2+ supplementation (WB/+Ca), simulated component therapy without Ca2+ supplementation (COMP/-Ca), or simulated component therapy with Ca2+ supplementation (COMP/+Ca). Resuscitation occurred during continued hemorrhage, followed by 4 hours of monitoring. The primary outcome was mean arterial pressure (MAP) after completion of transfusion. Secondary outcomes included survival, ionized and serum Ca2+, potassium, and lactate.
RESULTS: Baseline values were similar across groups. Survival was 3 of 8 animals in COMP/-Ca and 8 of 8 animals in each other group (log-rank P < .001). MAP differed significantly between groups over time (P < .001), with lower MAP in COMP/-Ca compared with WB/-Ca (P = .0036), WB/+Ca (P = .0046), and COMP/+Ca (P = .0076). Ionized Ca2+ was lowest in COMP/-Ca.
CONCLUSIONS: In this polytrauma model, simulated COMP with excess citrate and without Ca2+ supplementation was associated with lower ionized Ca2+, hemodynamic instability, and decreased survival. These findings support further investigation into how citrate burden and Ca2+ supplementation strategies influence massive transfusion physiology during WB and COMP-based resuscitation.
METHODS: In a randomized swine (Sus scrofa) polytrauma model, 32 castrated male and nonpregnant females underwent tibial fracture, blunt liver injury, 30% controlled hemorrhage, and a 30-minute shock period. Animals were assigned to WB without Ca2+ supplementation (WB/-Ca), WB with Ca2+ supplementation (WB/+Ca), simulated component therapy without Ca2+ supplementation (COMP/-Ca), or simulated component therapy with Ca2+ supplementation (COMP/+Ca). Resuscitation occurred during continued hemorrhage, followed by 4 hours of monitoring. The primary outcome was mean arterial pressure (MAP) after completion of transfusion. Secondary outcomes included survival, ionized and serum Ca2+, potassium, and lactate.
RESULTS: Baseline values were similar across groups. Survival was 3 of 8 animals in COMP/-Ca and 8 of 8 animals in each other group (log-rank P < .001). MAP differed significantly between groups over time (P < .001), with lower MAP in COMP/-Ca compared with WB/-Ca (P = .0036), WB/+Ca (P = .0046), and COMP/+Ca (P = .0076). Ionized Ca2+ was lowest in COMP/-Ca.
CONCLUSIONS: In this polytrauma model, simulated COMP with excess citrate and without Ca2+ supplementation was associated with lower ionized Ca2+, hemodynamic instability, and decreased survival. These findings support further investigation into how citrate burden and Ca2+ supplementation strategies influence massive transfusion physiology during WB and COMP-based resuscitation.