Journal francais d'ophtalmologie · 2026
Impact of proton beam radiation therapy on conduction of visual information as assessed by visual evoked potentials in patients with brain or head and neck tumors: A bicentric prospective study.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Anger E, Thariat J, Laville M, Marty P-A, Quintyn J-C
Аннотация
PURPOSE: To investigate early optic nerve damage by analyzing visual evoked potentials (VEP) before and after proton beam radiation therapy.
METHODS: Seventy-one adult patients (142 eyes) who received proton beam radiation therapy and underwent ophthalmological assessments including VEP, optical coherence tomography (OCT) and visual field perimetry at baseline and 6, 12, and 18 months post-treatment were included in this bicentric prospective study.
RESULTS: The median age was 63.1 years, with female predominance (63.1%). Tumors included meningiomas (43.7%, n=31), pituitary adenomas (19.7%, n=14), and nasal sinus or cutaneous carcinomas (12.7%, n=9). Baseline VEP values were below normal: pattern 60' peak time=112ms for 6.55mV, pattern 30'=115ms for 7mV, pattern 15'=123ms for 6.05mV. Abnormal VEP values were observed in 78% of patients prior to radiation therapy. Peak time increased significantly at each of the follow up visits for Pa60' and Pa30', peaking at 18 months post-treatment (+6ms, P<0.01). Amplitudes showed a non-significant downward trend, peaking at 18 months. VEP peak time and amplitudes did not correlate with other visual outcome measures (ETDRS acuity, OCT RNFL thickness, or perimetry).
CONCLUSION: VEPs may serve as an early, non-invasive indicator of radiation-induced optic neuropathy (RION) and should be considered in multidisciplinary monitoring protocols for patients undergoing proton beam radiation therapy.
METHODS: Seventy-one adult patients (142 eyes) who received proton beam radiation therapy and underwent ophthalmological assessments including VEP, optical coherence tomography (OCT) and visual field perimetry at baseline and 6, 12, and 18 months post-treatment were included in this bicentric prospective study.
RESULTS: The median age was 63.1 years, with female predominance (63.1%). Tumors included meningiomas (43.7%, n=31), pituitary adenomas (19.7%, n=14), and nasal sinus or cutaneous carcinomas (12.7%, n=9). Baseline VEP values were below normal: pattern 60' peak time=112ms for 6.55mV, pattern 30'=115ms for 7mV, pattern 15'=123ms for 6.05mV. Abnormal VEP values were observed in 78% of patients prior to radiation therapy. Peak time increased significantly at each of the follow up visits for Pa60' and Pa30', peaking at 18 months post-treatment (+6ms, P<0.01). Amplitudes showed a non-significant downward trend, peaking at 18 months. VEP peak time and amplitudes did not correlate with other visual outcome measures (ETDRS acuity, OCT RNFL thickness, or perimetry).
CONCLUSION: VEPs may serve as an early, non-invasive indicator of radiation-induced optic neuropathy (RION) and should be considered in multidisciplinary monitoring protocols for patients undergoing proton beam radiation therapy.