Transplantation proceedings · 2025
Sclerosing Encapsulating Peritonitis: A Surgical Challenge in Liver Transplantation.
СтатьяКлинический случайНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Lorenzo Claudia, Chullo Gabriela, Tonina Emilio Domingo, Rivas Eva, Blasi Annabel, Ubre Marta, Crespo Gonzalo, Ruiz Pablo, Colmenero Jordi, Pera Miguel, Fundora Yiliam
Аннотация
UNLABELLED: Sclerosing Encapsulating Peritonitis (SEP) is a rare condition characterized by chronic inflammation of the peritoneum, of either idiopathic origin or sometimes due to local or systemic factors. The symptoms are often non-specific, and in many cases, the diagnosis is only made during laparotomy or laparoscopy. In severe cases, SEP can be a contraindication for liver transplantation because of the associated risk of surgical complications.
METHOD: To report on the incidence and management of SEP identified during liver transplantation at our center, and to document the associated Serious Adverse Events (SAEs).
RESULTS: We present a series of 3 cases from 2022 to 2023, where SEP was diagnosed intraoperatively. These cases were marked by significant technical challenges, including extensive adhesions, dense fibrous encapsulations, and severe intraoperative hemorrhage necessitating blood transfusions. Despite these complexities, all transplants were successfully completed. One patient experienced a peak serum AST of 2000 U/L, and another had a bilirubin of 10 mg/dL, indicative of early graft dysfunction, both of which resolved within the first week. One patient required an emergency laparotomy due to hemorrhage. No additional severe complications were observed postoperatively. All patients are currently alive with functioning grafts and have been followed for at least 18 months.
CONCLUSIONS: A multidisciplinary approach and advanced surgical planning are crucial for successfully performing complex liver transplants in patients with SEP. Intraoperative recognition of SEP requires meticulous strategies to minimize blood loss and optimize hemostasis, while avoiding organ injuries, as these factors are critical for improving the survival outcomes in these patients.
METHOD: To report on the incidence and management of SEP identified during liver transplantation at our center, and to document the associated Serious Adverse Events (SAEs).
RESULTS: We present a series of 3 cases from 2022 to 2023, where SEP was diagnosed intraoperatively. These cases were marked by significant technical challenges, including extensive adhesions, dense fibrous encapsulations, and severe intraoperative hemorrhage necessitating blood transfusions. Despite these complexities, all transplants were successfully completed. One patient experienced a peak serum AST of 2000 U/L, and another had a bilirubin of 10 mg/dL, indicative of early graft dysfunction, both of which resolved within the first week. One patient required an emergency laparotomy due to hemorrhage. No additional severe complications were observed postoperatively. All patients are currently alive with functioning grafts and have been followed for at least 18 months.
CONCLUSIONS: A multidisciplinary approach and advanced surgical planning are crucial for successfully performing complex liver transplants in patients with SEP. Intraoperative recognition of SEP requires meticulous strategies to minimize blood loss and optimize hemostasis, while avoiding organ injuries, as these factors are critical for improving the survival outcomes in these patients.