Fertility and sterility · 2010
Imatinib decreases endometrial stromal cell transmesothial migration and proliferation in the extracellular matrix of modeled peritoneum.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Griffith Jason S, Binkley Peter A, Kirma Namir B, Schenken Robert S, Witz Craig A, Tekmal Rajeshwar R
Аннотация
OBJECTIVE: To characterize imatinib's effect on endometrial stromal cell (ESC) attachment, proliferation, and invasion in modeled peritoneum.
DESIGN: In vitro study.
SETTING: Academic medical center.
PATIENT(S): Twelve normally cycling women.
INTERVENTION(S): Imatinib treatment in ESCs from women without endometriosis.
MAIN OUTCOME MEASURE(S): Rate of ESC attachment, proliferation, and invasion.
RESULT(S): Imatinib treatment at 10 μM had no effect on ESC attachment. Treatment with 0.5 μM, 2 μM, and 10 μM of imatinib reduced ESC proliferation by 30%, 72%, and 76%, respectively. The 0.1 μM dose of imatinib had no effect on proliferation. Treatment with 5 μM and 10 μM of imatinib reduced ESC invasion by 30% and 73%, respectively. The 2 μM dose had no effect on invasion.
CONCLUSION(S): Imatinib treatment reduces ESC proliferation and invasion in modeled peritoneum without altering attachment. Imatinib may have a therapeutic role in endometriosis treatment.
DESIGN: In vitro study.
SETTING: Academic medical center.
PATIENT(S): Twelve normally cycling women.
INTERVENTION(S): Imatinib treatment in ESCs from women without endometriosis.
MAIN OUTCOME MEASURE(S): Rate of ESC attachment, proliferation, and invasion.
RESULT(S): Imatinib treatment at 10 μM had no effect on ESC attachment. Treatment with 0.5 μM, 2 μM, and 10 μM of imatinib reduced ESC proliferation by 30%, 72%, and 76%, respectively. The 0.1 μM dose of imatinib had no effect on proliferation. Treatment with 5 μM and 10 μM of imatinib reduced ESC invasion by 30% and 73%, respectively. The 2 μM dose had no effect on invasion.
CONCLUSION(S): Imatinib treatment reduces ESC proliferation and invasion in modeled peritoneum without altering attachment. Imatinib may have a therapeutic role in endometriosis treatment.
Предметные рубрики MeSH
Antineoplastic AgentsBenzamidesCell AdhesionCell Culture TechniquesCell ProliferationCells, CulturedDown-RegulationDrug Evaluation, PreclinicalEndometriumEpitheliumExtracellular MatrixFemaleHumansImatinib MesylateModels, BiologicalPeritoneumPiperazinesPyrimidinesStromal CellsTransendothelial and Transepithelial Migration