Journal of the neurological sciences · 2013
A brief olfactory test for Alzheimer's disease.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Stamps Jennifer J, Bartoshuk Linda M, Heilman Kenneth M
Аннотация
BACKGROUND: The early diagnosis of Alzheimer's disease (AD) may help reduce disability, enhance quality of life, and aid clinical trials. Portions of olfactory cortex are the initial sites of AD pathology and patients with AD often have more degeneration of their left than right hemisphere. Since the olfactory epithelium projects mainly to the ipsilateral olfactory cortex, patients with AD may demonstrate an asymmetrical (left greater than right) decrement of odor detection sensitivity. This retrospective, case-control study assessed a quick olfactory test that may help diagnose AD.
METHODS: Participants with probable AD (N=18), mild cognitive impairment (MCI, N=24), other causes of dementia (OD, N=26) and matched controls (OC, N=26) were tested, with closed eyes, for their ability to detect an odor, one nostril at a time. A container of 14g of peanut butter was opened, held medially at the bottom of a 30cm ruler, and moved up 1cm at a time during the participants' exhale. Upon odor detection, the distance between the subject's nostril and container was measured.
RESULTS: The mean odor detection distance of AD patients' left nostril (5.1cm), and not their right (17.4cm), was significantly less (F(3,90)=22.28, p<0.0001) than the other groups. The mean, standard error, and 95% Confidence Interval of the L-R nostril odor detection difference (cm) for AD were -12.4±0.5, (-15.0,-9.8); for MCI were -1.9±1.2, (-4.2,0.4); for OD were 4.8±1.0, (2.6,6.9); and for OC were 0.0±1.4 (-2.2,2.1).
CONCLUSION: This non-invasive and inexpensive left-right nostril odor detection test appears to be a sensitive and specific test for probable AD.
METHODS: Participants with probable AD (N=18), mild cognitive impairment (MCI, N=24), other causes of dementia (OD, N=26) and matched controls (OC, N=26) were tested, with closed eyes, for their ability to detect an odor, one nostril at a time. A container of 14g of peanut butter was opened, held medially at the bottom of a 30cm ruler, and moved up 1cm at a time during the participants' exhale. Upon odor detection, the distance between the subject's nostril and container was measured.
RESULTS: The mean odor detection distance of AD patients' left nostril (5.1cm), and not their right (17.4cm), was significantly less (F(3,90)=22.28, p<0.0001) than the other groups. The mean, standard error, and 95% Confidence Interval of the L-R nostril odor detection difference (cm) for AD were -12.4±0.5, (-15.0,-9.8); for MCI were -1.9±1.2, (-4.2,0.4); for OD were 4.8±1.0, (2.6,6.9); and for OC were 0.0±1.4 (-2.2,2.1).
CONCLUSION: This non-invasive and inexpensive left-right nostril odor detection test appears to be a sensitive and specific test for probable AD.