Ophthalmology. Retina · 2026
Efficacy of Prophylactic Laser Treatment of Lattice Degeneration in the Fellow Eyes of Patients with Retinal Breaks in the First Eye.
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Ni Roselind L, Adams Olufemi E, Momenaei Bita, Yu Julia, Chiang Allen, Fineman Mitchell S, Spirn Marc J, Hsu Jason
Аннотация
OBJECTIVE: To assess the effect of prophylactic treatment (PTx) of lattice degeneration on retinal break and rhegmatogenous retinal detachment (RRD) risk in fellow eyes of patients with bilateral lattice degeneration treated for retinal breaks without retinal detachment (RD) in the first eye.
DESIGN: Retrospective cohort study.
SUBJECTS: Patients with lattice degeneration in both eyes who were treated for retinal breaks in one eye. Patients with <2 years of follow-up since first eye treatment, prior RRD, pars plana vitrectomy, bilateral retinal breaks, or laser treatment in either eye before the first visit were excluded.
METHODS: The incidence of new retinal breaks and RD was compared between fellow eyes with and without PTx.
MAIN OUTCOME MEASURES: Proportion of eyes developing retinal breaks or RRD in fellow eyes that received PTx compared with those that did not.
RESULTS: The study included 802 patients. The mean (standard deviation [SD]) age was 53.5 (14.2) years, with a mean follow-up duration of 5.2 (2.3) years. Among the fellow eyes, 83 (10.3%) received PTx for lattice degeneration after a mean (SD) interval of 22.3 (25.7) months after initial treatment of the first eye, whereas 719 (89.7%) did not. During the follow-up period, RRD occurred in 5 of the 83 eyes (6%) with PTx and in 36 of the 719 eyes (5%) without PTx, with no significant difference between the 2 groups (P = 0.603). New retinal breaks were observed in 18 of the 83 eyes (21.7%) with PTx and in 157 of the 719 eyes (21.8%) without PTx, also showing no significant difference (P > 0.99). The composite endpoint of new retinal breaks or RRD occurred in 20 of 83 (24.1%) prophylactically treated eyes (3 eyes with both new break and RRD) and 179 of 719 (24.9%) nonprophylactically treated eyes (14 eyes with both new break and RRD) (P = 0.87).
CONCLUSIONS: Subsequent PTx of fellow eyes did not lower the risk of retinal breaks or RRD development in patients with bilateral lattice degeneration who developed retinal breaks in the first eye over a mean follow-up period of 5 years.
FINANCIAL DISCLOSURES: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
DESIGN: Retrospective cohort study.
SUBJECTS: Patients with lattice degeneration in both eyes who were treated for retinal breaks in one eye. Patients with <2 years of follow-up since first eye treatment, prior RRD, pars plana vitrectomy, bilateral retinal breaks, or laser treatment in either eye before the first visit were excluded.
METHODS: The incidence of new retinal breaks and RD was compared between fellow eyes with and without PTx.
MAIN OUTCOME MEASURES: Proportion of eyes developing retinal breaks or RRD in fellow eyes that received PTx compared with those that did not.
RESULTS: The study included 802 patients. The mean (standard deviation [SD]) age was 53.5 (14.2) years, with a mean follow-up duration of 5.2 (2.3) years. Among the fellow eyes, 83 (10.3%) received PTx for lattice degeneration after a mean (SD) interval of 22.3 (25.7) months after initial treatment of the first eye, whereas 719 (89.7%) did not. During the follow-up period, RRD occurred in 5 of the 83 eyes (6%) with PTx and in 36 of the 719 eyes (5%) without PTx, with no significant difference between the 2 groups (P = 0.603). New retinal breaks were observed in 18 of the 83 eyes (21.7%) with PTx and in 157 of the 719 eyes (21.8%) without PTx, also showing no significant difference (P > 0.99). The composite endpoint of new retinal breaks or RRD occurred in 20 of 83 (24.1%) prophylactically treated eyes (3 eyes with both new break and RRD) and 179 of 719 (24.9%) nonprophylactically treated eyes (14 eyes with both new break and RRD) (P = 0.87).
CONCLUSIONS: Subsequent PTx of fellow eyes did not lower the risk of retinal breaks or RRD development in patients with bilateral lattice degeneration who developed retinal breaks in the first eye over a mean follow-up period of 5 years.
FINANCIAL DISCLOSURES: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.