Effects of concentrated growth factor combined with Bio-Oss bone powder on guided bone regeneration in the maxillary posterior region.

OBJECTIVE

To evaluate the clinical effects of concentrated growth factor (CGF) combined with Bio-Oss bone powder on guided bone regeneration for the maxillary posterior region.

METHODS

This retrospective study included 32 patients with missing maxillary posterior teeth and severe alveolar ridge atrophy requiring implant restoration for retrospective analysis. Sixteen patients received CGF combined with Bio-Oss treatment (CGF/Bio group), while the remaining 16 received Bio-Oss treatment only (Bio group). The Bio group used Bio-Oss bone powder directly. Cone-beam computed tomography (CBCT) was performed preoperatively and at 2, 4, and 6 months postoperatively to evaluate bone mineral density (HU values). The implant retention rate, soft tissue healing time, postoperative pain, and swelling were also evaluated.

RESULTS

The 1-year implant retention rate was 100% in the CGF/Bio group and 81.25% in the Bio group (P = 0.054). Soft tissue healing time was significantly shorter in the CGF/Bio group (P = 0.122). Bone density was significantly higher in the CGF/Bio group at 2, 4, and 6 months postoperatively (P < 0.05). Postoperative pain and swelling were significantly lower in the CGF/Bio group (P = 0.008 and P = 0.014, respectively).

CONCLUSION

The combined application of CGF and Bio-Oss bone powder in maxillary sinus external lift demonstrates superior clinical outcomes, offering improved bone augmentation and enhanced postoperative healing compared to Bio-Oss bone powder alone.