Pituitary · 2024
Pituitary hypophysitis in granulomatosis with polyangiitis (GPA): a case series.
СтатьяНазвание и аннотация: Перевод в очереди
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Alameri Majid, Alnuaimi Abdulla, Martin Niamh M, Meeran Karim, Gontsarova Anastasia, Barwick Tara D, Ellis Spencer, McAdoo Stephen, Tomlinson James, Wernig Florian
Аннотация
Granulomatosis with polyangiitis (GPA) rarely involves the pituitary gland. Pituitary involvement has been reported in ~ 1% of all cases of GPA. Most commonly, pituitary swelling and inflammation results in symptoms due to pituitary mass effect and arginine vasopressin deficiency. To date, there are no pituitary-specific treatment guidelines for this rare condition. We present three patients with GPA-related hypophysitis highlighting the spectrum of pituitary involvement. All three patients were successfully treated with immunosuppressive regimens that included rituximab (RTX). Following remission induction with high-dose glucocorticoids, patients received 6 monthly RTX for remission maintenance. RTX was well tolerated without significant side effects.