Placenta · 2026
Insights in the (patho)physiology of uterine activity in the first 30 min after childbirth.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Berben Phebe B Q, Messing Femke M, de Vries Ivar R, Dieleman Jeanne P, Fransen Annemarie F, van der Ven Myrthe, van der Hout-van der Jagt M Beatrijs, Oei S Guid, van Laar Judith O E H
Аннотация
INTRODUCTION: The incidence of postpartum hemorrhage (PPH) has increased despite consistent use of prophylactic treatment. To date, little is known about postpartum uterine activity. This study investigates the association between various uterine activity parameters and blood loss in the first 30 min postpartum.
MATERIAL AND METHODS: Term pregnant patients who received postpartum continuous electrophysiological uterine monitoring were included. Postpartum blood loss was measured using weighting. From a 30-min electrohysterography-derived tocogram, a computer-based algorithm was used to extract uterine activity parameters. These included total area under the curve (AUC), AUC from baseline, maximum amplitude and baseline tone. Scatterplots between various UA parameters and logarithmically transformed total blood loss were made and Pearson correlation coefficients were calculated. UA-parameters were compared between non-PPH patients and patients with PPH, including the different PPH etiologies.
RESULTS: 119 patients were included of which 24 had PPH (blood loss ≥500 mL). Total blood loss showed no significant association with the various UA-parameters. Patients with PPH due to a retained placenta (n = 6) showed significantly higher total UA-AUC (5.5 vs 5.2, p = 0.007), UA-AUC from baseline (5.4 vs 5.1, p = 0.003) and maximum amplitude (3.0 vs 2.9, p = 0.024) compared to patients without PPH.
CONCLUSION: Increased postpartum uterine activity may reflect compensatory but ineffective myometrial activation in patients with PPH due to a retained placenta. Due to the limited sample size and exploratory nature of the analyses, these results should be interpreted with caution.
MATERIAL AND METHODS: Term pregnant patients who received postpartum continuous electrophysiological uterine monitoring were included. Postpartum blood loss was measured using weighting. From a 30-min electrohysterography-derived tocogram, a computer-based algorithm was used to extract uterine activity parameters. These included total area under the curve (AUC), AUC from baseline, maximum amplitude and baseline tone. Scatterplots between various UA parameters and logarithmically transformed total blood loss were made and Pearson correlation coefficients were calculated. UA-parameters were compared between non-PPH patients and patients with PPH, including the different PPH etiologies.
RESULTS: 119 patients were included of which 24 had PPH (blood loss ≥500 mL). Total blood loss showed no significant association with the various UA-parameters. Patients with PPH due to a retained placenta (n = 6) showed significantly higher total UA-AUC (5.5 vs 5.2, p = 0.007), UA-AUC from baseline (5.4 vs 5.1, p = 0.003) and maximum amplitude (3.0 vs 2.9, p = 0.024) compared to patients without PPH.
CONCLUSION: Increased postpartum uterine activity may reflect compensatory but ineffective myometrial activation in patients with PPH due to a retained placenta. Due to the limited sample size and exploratory nature of the analyses, these results should be interpreted with caution.