Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2009
[Basic experimental and clinical research on peritoneal dialysis in the past 16 years].
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Liu Fuyou, Peng Youming, Zou Shalin, Ling Guanghui, Nie Jing, Tang Wenbin, Zhou Xun, Duan Shaobin, Li Jun, Liu Yinghong, Liu Hong, Yuan Fang, Xiao Li, Zhuo Li, Chen Junxiang, Chen Xing, Cheng Meichu, Zhu Jianling, Zhu Xiaoping, Luo Ji' an, Fan Min, Zhang Hao, Sun Lin
Аннотация
To summarized the experiences from our basic experimental and clinical research on peritoneal dialysis. In the past 16 years, peritoneal fibrosis rat models and rabbit models of peritonitis were first established successfully in our laboratory in China. Peritoneal mesothelial cells were also separated and identificated. Besides, we assessed the biocompatibility of peritoneal dialysis fluid and analyzed the molecular mechanism of peritoneal mesothelial cell injury. We demonstrated the key role of transforming growth factor-beta1 (TGF-beta1), connective tissue growth factor (CTGF) and peroxisome proliferative activated receptor-gamma (PPAR-gamma) in the pathogenesis of peritoneal fibrosis, as well as their regulation of molecular mechanism. Furthermore, we transfected the plasmids encoding TGF-beta1-shRNA or pCTGF-shRNA into peritoneal cells and tissues by nanocarrier technologies. In clinical research, the positioning of peritoneal dialysis catheters, peritoneal dialysis treatment modalities and the prevention and treatment of its complications were studied. The characteristics and mechanism of solute transport in peritoneal dialysis was also explored.