Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2025
Prognostic significance of surgical margins in laryngeal cancer treated by transoral laser microsurgery: a systematic review and meta-analysis.
СтатьяСистематический обзорМетаанализНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
De Virgilio Armando, Pagliuca Giulio, Russo Elena, Crosetti Erika, Motta Giovanni, Peretti Giorgio, Greco Antonio, Succo Giovanni, de Vincentiis Marco, Gallo Andrea
Аннотация
OBJECTIVE: To evaluate the prognostic significance of surgical margins in patients undergoing transoral laser microsurgery (TLM) for laryngeal squamous cell carcinoma (LSCC).
METHODS: A comprehensive literature search was conducted in PubMed/MEDLINE, Cochrane Library, Scopus, and Google Scholar following PRISMA guidelines. Studies comparing oncologic outcomes between positive and negative resection margins were included. Hazard ratios (HRs) for local control (LC), disease-free survival (DFS), and overall survival (OS) were extracted and pooled using a random-effects model to account for inter-study variability.
RESULTS: A total of 26 studies, including 5,463 patients, met inclusion criteria. The pooled log-HR for DFS was 0.93 (p < 0.05), indicating a significantly higher risk of recurrence in patients with positive margins. However, no significant differences were observed for LC (log-HR = -0.76, p = 0.59) or OS (log-HR = 0.16, p = 0.40).
CONCLUSIONS: While positive surgical margins significantly impact DFS, their effect on LC and OS remains uncertain. Further prospective studies are necessary to refine treatment guidelines and optimise oncologic outcomes.
METHODS: A comprehensive literature search was conducted in PubMed/MEDLINE, Cochrane Library, Scopus, and Google Scholar following PRISMA guidelines. Studies comparing oncologic outcomes between positive and negative resection margins were included. Hazard ratios (HRs) for local control (LC), disease-free survival (DFS), and overall survival (OS) were extracted and pooled using a random-effects model to account for inter-study variability.
RESULTS: A total of 26 studies, including 5,463 patients, met inclusion criteria. The pooled log-HR for DFS was 0.93 (p < 0.05), indicating a significantly higher risk of recurrence in patients with positive margins. However, no significant differences were observed for LC (log-HR = -0.76, p = 0.59) or OS (log-HR = 0.16, p = 0.40).
CONCLUSIONS: While positive surgical margins significantly impact DFS, their effect on LC and OS remains uncertain. Further prospective studies are necessary to refine treatment guidelines and optimise oncologic outcomes.