Successful Sequential Treatment From Remdesivir to Molnupiravir for Prolonged COVID-19 in a Patient With Follicular Lymphoma and Renal Pelvic Carcinoma: A Case Report.

A 69-year-old Japanese male with follicular lymphoma and renal pelvic carcinoma presented with fever and cough, testing positive for SARS-CoV-2 via PCR. Chest CT revealed ground-glass opacities. Initially, his symptoms improved with a 10-day course of remdesivir (RDV), but they recurred. On day 42, a second 10-day course of RDV combined with dexamethasone was initiated; however, symptoms persisted, and his SARS-CoV-2 PCR test remained positive on day 72. Subsequently, a successful treatment regimen of 10 days of RDV followed by five days of molnupiravir (MOL) was administered. This study represents the first reported case of persistent SARS-CoV-2 infection successfully treated with sequential therapy transitioning from RDV to MOL, without extending the treatment duration.