Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024
Mobile Phone Use and Risks of Overall and 25 Site-Specific Cancers: A Prospective Study from the UK Biobank Study.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Zhang Yanjun, Zhang Yuanyuan, Ye Ziliang, Yang Sisi, Liu Mengyi, Wu Qimeng, Zhou Chun, He Panpan, Gan Xiaoqin, Qin Xianhui
Аннотация
BACKGROUND: The association between mobile phone use and incident cancers remains uncertain. We aimed to investigate the relationships of mobile phone use with incident overall and 25 site-specific cancers in men and women.
METHODS: A total of 431,861 participants ages 38 to 73 years without prior cancers were included from the UK Biobank. Of these, 46.7% were male. Participants who used a mobile phone at least once per week to make or receive calls were defined as mobile phone users. The study outcomes were incident overall and 25 site-specific cancers.
RESULTS: During a median follow-up of 10.7 years, 35,401 (17.5%) men and 30,865 (13.4%) women developed overall cancer. Mobile phone use was significantly associated with higher risks of incident overall cancer [HR, 1.09; 95% confidence interval (CI): 1.06-1.12], nonmelanoma skin cancer (NMSC; HR, 1.08; 95% CI: 1.03-1.14), urinary tract cancer (HR, 1.18; 95% CI:1.05-1.32), and prostate cancer (HR, 1.19; 95% CI: 1.13-1.25) in men, and incident overall cancer (HR, 1.03; 95% CI: 1.00-1.06), NMSC (HR, 1.07; 95% CI: 1.01-1.13), and vulva cancer (HR, 1.74; 95% CI: 1.00-3.02) in women, but not with other cancers. Among mobile phone users, there was a dose-response relationship of length of mobile phone use with incident NMSC in men and women, and prostate cancer in men (all Ptrend < 0.05).
CONCLUSIONS: There was a dose-response relationship of length of mobile phone use with incident NMSC in men and women, and prostate cancer in men.
IMPACT: Our findings underscore the importance of limiting mobile phone use or keeping a distance from mobile phone for primary prevention of NMSC and prostate cancer.
METHODS: A total of 431,861 participants ages 38 to 73 years without prior cancers were included from the UK Biobank. Of these, 46.7% were male. Participants who used a mobile phone at least once per week to make or receive calls were defined as mobile phone users. The study outcomes were incident overall and 25 site-specific cancers.
RESULTS: During a median follow-up of 10.7 years, 35,401 (17.5%) men and 30,865 (13.4%) women developed overall cancer. Mobile phone use was significantly associated with higher risks of incident overall cancer [HR, 1.09; 95% confidence interval (CI): 1.06-1.12], nonmelanoma skin cancer (NMSC; HR, 1.08; 95% CI: 1.03-1.14), urinary tract cancer (HR, 1.18; 95% CI:1.05-1.32), and prostate cancer (HR, 1.19; 95% CI: 1.13-1.25) in men, and incident overall cancer (HR, 1.03; 95% CI: 1.00-1.06), NMSC (HR, 1.07; 95% CI: 1.01-1.13), and vulva cancer (HR, 1.74; 95% CI: 1.00-3.02) in women, but not with other cancers. Among mobile phone users, there was a dose-response relationship of length of mobile phone use with incident NMSC in men and women, and prostate cancer in men (all Ptrend < 0.05).
CONCLUSIONS: There was a dose-response relationship of length of mobile phone use with incident NMSC in men and women, and prostate cancer in men.
IMPACT: Our findings underscore the importance of limiting mobile phone use or keeping a distance from mobile phone for primary prevention of NMSC and prostate cancer.