Journal of biomedical optics · 2026
Corneal dose response from exposure to a Q-switched laser at a central wavelength of 1645 nm using a rabbit model.
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Chue-Sang Joseph J, Peralta Xomalin G, Clary Joseph E, Smith Andrea, Peterson Amanda, Macasadia Matthew E, Tijerina Amanda J, Noojin Gary D, Hart Maximillian V, Schwarten Charles F, Kinerk Wesley T, Ferris Lyndsey M, Boice Emily N
Аннотация
SIGNIFICANCE: Laser safety studies of the eye are well documented for visible wavelength and continuous wave lasers. There are fewer experimental results for infrared wavelengths and pulsed lasers.
AIM: We aim to fill the gap at 1645 nm for single nanosecond pulse duration exposures of rabbit cornea and determine the threshold radiant exposure to generate lesions 50% of the time (estimated dose ED 50 ).
APPROACH: Images of the cornea during exposures were acquired using slit lamp microscopy and optical coherence tomography. A histological analysis helped provide dosimetry relationships with morphology and mechanisms of the damage.
RESULTS: We measured the energy ED 50 value at 3.86 ± 0.085 mJ utilizing the slit lamp biomicroscopy. Incorporating the experimental spot size diameter, this corresponds to a peak radiant exposure of 102 J / cm 2 . By contrast, the average radiant exposure ED 50 over a 1-mm diameter limiting aperture as per the ANSI Z.136 convention was 0.49 J / cm 2 . Additional analysis via optical coherence tomography (OCT) and histology examined the severity and degree of damage.
CONCLUSION: This experimental approach performed well to characterize damage and identify damage thresholds to inform the laser safety standard community of the accuracy of current exposure limits.
AIM: We aim to fill the gap at 1645 nm for single nanosecond pulse duration exposures of rabbit cornea and determine the threshold radiant exposure to generate lesions 50% of the time (estimated dose ED 50 ).
APPROACH: Images of the cornea during exposures were acquired using slit lamp microscopy and optical coherence tomography. A histological analysis helped provide dosimetry relationships with morphology and mechanisms of the damage.
RESULTS: We measured the energy ED 50 value at 3.86 ± 0.085 mJ utilizing the slit lamp biomicroscopy. Incorporating the experimental spot size diameter, this corresponds to a peak radiant exposure of 102 J / cm 2 . By contrast, the average radiant exposure ED 50 over a 1-mm diameter limiting aperture as per the ANSI Z.136 convention was 0.49 J / cm 2 . Additional analysis via optical coherence tomography (OCT) and histology examined the severity and degree of damage.
CONCLUSION: This experimental approach performed well to characterize damage and identify damage thresholds to inform the laser safety standard community of the accuracy of current exposure limits.